Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 554039
Title Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice
Author(s) Udayappan, Shanthadevi; Manneras-Holm, Louise; Chaplin-Scott, Alice; Belzer, Clara; Herrema, Hilde; Dallinga-Thie, Geesje M.; Duncan, Silvia H.; Stroes, Erik S.G.; Groen, Albert K.; Flint, Harry J.; Backhed, Fredrik; Vos, Willem M. De; Nieuwdorp, Max
Source npj Biofilms and Microbiomes 2 (2016). - ISSN 2055-5008
DOI https://doi.org/10.1038/npjbiofilms.2016.9
Department(s) MolEco
VLAG
Microbiology
BacGen
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract

An altered intestinal microbiota composition is associated with insulin resistance and type 2 diabetes mellitus. We previously identified increased intestinal levels of Eubacterium hallii, an anaerobic bacterium belonging to the butyrate-producing Lachnospiraceae family, in metabolic syndrome subjects who received a faecal transplant from a lean donor. To further assess the effects of E. hallii on insulin sensitivity, we orally treated obese and diabetic db/db mice with alive E. hallii and glycerol or heatinactive E. hallii as control. Insulin tolerance tests and hyperinsulinemic-euglycemic clamp experiments revealed that alive E. hallii treatment improved insulin sensitivity compared control treatment. In addition, E. hallii treatment increased energy expenditure in db/db mice. Active E. hallii treatment was found to increase faecal butyrate concentrations and to modify bile acid metabolism compared with heat-inactivated controls. Our data suggest that E. hallii administration potentially alters the function of the intestinal microbiome and that microbial metabolites may contribute to the improved metabolic phenotype.

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