Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 554193
Title Changes in body weight in patients with colorectal cancer treated with surgery and adjuvant chemotherapy: An observational study
Author(s) Winkels, Renate M.; Snetselaar, Teunise; Adriaans, Anika; Warmerdam, Laurens J.C. van; Vreugdenhil, A.; Slooter, G.D.; Straathof, J.W.; Kampman, Ellen; Lieshout, Rianne van; Beijer, Sandra
Source Cancer Treatment and Research Communications 9 (2016). - ISSN 2468-2942 - p. 111 - 115.
DOI https://doi.org/10.1016/j.ctarc.2016.09.002
Department(s) VLAG
Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Adjuvant therapy - Colon and rectal cancer - Survivorship
Abstract

Background and objectives Prevalence of overweight and obesity is high among colorectal cancer patients upon diagnosis. Body weight may change substantially during treatment for colorectal cancer. In this study, we describe changes in body weight in colorectal cancer patients during three periods: the period of surgery, during adjuvant chemotherapy and during oncological follow-up; in addition, we assess which clinical/personal factors were associated with weight change. Subject/Methods 485 stage II/III colorectal cancer patients diagnosed between 2007 and 2012 and treated with surgery and adjuvant chemotherapy in three hospitals in the Netherlands were identified through the Netherlands Cancer Registry. Data on changes in body weight were retrieved from medical records. Results Over the period of surgery, patients on average lost weight (mean −1.9 kg, SD 4.6 kg) (n=357). Weight increased during chemotherapy (2.9 kg, SD 5.8 kg) (n=291) and increased during oncological follow-up (2.2 kg, SD 6.6 kg) (n=242). Mean weight change over the total period was +2.0 kg (SD 6.8 kg) (n=283). Factors univariately associated with weight gain were normal BMI (vs a BMI of 25–30), open surgery (vs laparoscopic surgery) and Capecitabine monotherapy (vs Capecitabine plus Oxaliplatin). In a multivariate model, factors were no longer associated with weight gain. Conclusions Body weight generally decreased during surgery and increased during and after chemotherapy. During oncological follow-up, body weight generally was higher than upon diagnosis. Studies among other patient groups suggest that weight changes may primarily affect muscle mass, and may lead to e.g. sarcopenic obesity. Future prospective studies are needed to explore this in colorectal cancer patients.

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