Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 554238
Title Selection and gene flow shape niche-associated variation in pheromone response
Author(s) Lee, Daehan; Zdraljevic, Stefan; Cook, Daniel E.; Frézal, Lise; Hsu, Jung-Chen; Sterken, Mark G.; Riksen, Joost A.G.; Wang, John; Kammenga, Jan E.; Braendle, Christian; Félix, Marie-Anne; Schroeder, Frank C.; Andersen, Erik C.
Source Nature Ecology & Evolution 3 (2019). - ISSN 2397-334X - p. 1455 - 1463.
DOI https://doi.org/10.1038/s41559-019-0982-3
Department(s) Laboratory of Nematology
PE&RC
EPS
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract From quorum sensing in bacteria to pheromone signalling in social insects, chemical communication mediates interactions among individuals in local populations. In Caenorhabditis elegans, ascaroside pheromones can dictate local population density; high levels of pheromones inhibit the reproductive maturation of individuals. Little is known about how natural genetic diversity affects the pheromone responses of individuals from diverse habitats. Here, we show that a niche-associated variation in pheromone receptor genes contributes to natural differences in pheromone responses. We identified putative loss-of-function deletions that impair duplicated pheromone receptor genes (srg-36 and srg-37), which were previously shown to be lost in population-dense laboratory cultures. A common natural deletion in srg-37 arose recently from a single ancestral population that spread throughout the world; this deletion underlies reduced pheromone sensitivity across the global C. elegans population. We found that many local populations harbour individuals with a wild-type or a deletion allele of srg-37, suggesting that balancing selection has maintained the recent variation in this pheromone receptor gene. The two srg-37 genotypes are associated with niche diversity underlying boom-and-bust population dynamics. We hypothesize that human activities likely contributed to the gene flow and balancing selection of srg-37 variation through facilitating the migration of species and providing a favourable niche for the recently arisen srg-37 deletion.

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