Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 555610
Title Partial replacement of glucose by galactose in the post-weaning diet improves parameters of hepatic health
Author(s) Bouwman, Lianne M.S.; Swarts, Hans J.M.; Fernández-Calleja, José M.S.; Stelt, Inge van der; Schols, Henk; Oosting, Annemarie; Keijer, Jaap; Schothorst, Evert M. van
Source Journal of Nutritional Biochemistry 73 (2019). - ISSN 0955-2863
DOI https://doi.org/10.1016/j.jnutbio.2019.108223
Department(s) BU Toxicology, Novel Foods & Agrochains
Human and Animal Physiology
VLAG
Food Chemistry
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Galactose - Inflammation - Liver health - Post-weaning diet - SAA3 - Transcriptomics
Abstract

Replacing part of glucose with galactose in the post-weaning diet beneficially affects later life metabolic health in female mice. The liver is the main site of galactose metabolism, but the direct effects of this dietary intervention on the liver in the post-weaning period are not known. The aim of this study was to elucidate this. Weanling female mice (C57BL/6JRccHsd) were fed a starch containing diet with glucose (32 en%) monosaccharide (GLU), or a diet with glucose and galactose (1:1 both 16 en%) (GLU+GAL). Body weight, body composition, and food intake were determined weekly. After 3 weeks, mice were sacrificed, and serum and liver tissues were collected. Global hepatic mRNA expression was analyzed and hepatic triglyceride (TG) and glycogen contents were determined by enzymatic assays. Body weight and body composition were similar in both groups, despite higher food intake in mice on GLU+GAL diet. Hepatic TG content was lower in GLU+GAL-fed than GLU-fed females, while glycogen levels were unaffected. Analysis of global expression patterns of hepatic mRNA showed that mainly inflammation-related pathways were affected by the diet, which were predominantly downregulated in GLU+GAL-fed females compared to GLU-fed females. This reduction in inflammation in GLU+GAL-fed females was also reflected by decreased serum concentrations of acute phase protein Serum amyloid A 3. In conclusion, replacing part of glucose with galactose in the post-weaning diet reduces hepatic TG content and hepatic inflammation.

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