Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 555634
Title Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
Author(s) Sikdar, Sinjini; Joehanes, Roby; Joubert, Bonnie R.; Xu, Cheng Jian; Vives-Usano, Marta; Rezwan, Faisal I.; Felix, Janine F.; Ward, James M.; Guan, Weihua; Richmond, Rebecca C.; Brody, Jennifer A.; Küpers, Leanne K.; Baïz, Nour; Håberg, Siri E.; Smith, Jennifer A.; Reese, Sarah E.; Aslibekyan, Stella; Hoyo, Cathrine; Dhingra, Radhika; Markunas, Christina A.; Xu, Tao; Reynolds, Lindsay M.; Just, Allan C.; Mandaviya, Pooja R.; Ghantous, Akram; Bennett, Brian D.; Wang, Tianyuan; Consortium, The Bios; Bakulski, Kelly M.; Melen, Erik; Zhao, Shanshan; Jin, Jianping; Herceg, Zdenko; Meurs, Joyce Van; Taylor, Jack A.; Baccarelli, Andrea A.; Murphy, Susan K.; Liu, Yongmei; Munthe-Kaas, Monica Cheng; Deary, Ian J.; Nystad, Wenche; Waldenberger, Melanie; Annesi-Maesano, Isabella; Conneely, Karen; Jaddoe, Vincent W.V.; Arnett, Donna; Snieder, Harold; Kardia, Sharon L.R.; Relton, Caroline L.; Ong, Ken K.; Ewart, Susan; Moreno-Macias, Hortensia; Romieu, Isabelle; Sotoodehnia, Nona; Fornage, Myriam; Motsinger-Reif, Alison; Koppelman, Gerard H.; Bustamante, Mariona; Levy, Daniel; London, Stephanie J.
Source Epigenomics 11 (2019)13. - ISSN 1750-1911 - p. 1487 - 1500.
DOI https://doi.org/10.2217/epi-2019-0066
Department(s) Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) cigarette smoking - epigenetics - infant - maternal exposure - methylation
Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

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