Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 558261
Title Thyroid Toxicogenomics: A Multi-Organ Paradigm
Author(s) Jomaa, Barae
Source In: Toxicogenomics-Based Cellular Models / Kleinjans, J., Elsevier Inc. Academic Press - ISBN 9780123978622 - p. 159 - 189.
DOI https://doi.org/10.1016/B978012397862200009-7
Department(s) Toxicology
Publication type Peer reviewed book chapter
Publication year 2014
Keyword(s) Endocrine disruption - HPT-axis - Thyroid hormones - Toxicogenomics
Abstract

Alternatives to animal testing are presently being developed within integrated strategies for the testing of a wide range of chemical stressors that have adverse effects on the thyroid system. In contrast to several other toxicological endpoints, the number of studies using so-called 'omics technologies for studying thyroid hormone disruption is still very limited. In order to support the future development of thyroid toxicogenomics, the current chapter presents a detailed overview of the thyroid hormone system, the potential modes of action involved in chemically induced thyroid disruption, and currently available in vitro assays for detecting such disruption. The overview also suggests future directions for this up-and-coming field, including possibilities for 'omics-based assays as a valuable addition to the currently available integrated testing strategies.

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