Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 558551
Title A critical comparison of cellular and cell-free bioproduction systems
Author(s) Claassens, Nico J.; Burgener, Simon; Vögeli, Bastian; Erb, Tobias J.; Bar-Even, Arren
Source Current Opinion in Biotechnology 60 (2019). - ISSN 0958-1669 - p. 221 - 229.
DOI https://doi.org/10.1016/j.copbio.2019.05.003
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

Conversion of biological feedstocks into value-added chemicals is mostly performed via microbial fermentation. An emerging alternative approach is the use of cell-free systems, consisting of purified enzymes and cofactors. Unfortunately, the in vivo and in vitro research communities rarely interact, which leads to oversimplifications and exaggerations that do not permit fair comparison of the two strategies and impede synergistic interactions. Here, we provide a comprehensive account for the advantages and drawbacks associated with each strategy, and further discuss recent research efforts that aim to breach the limits of cellular and cell-free production. We also explore emerging hybrid solutions that integrate the benefits of both worlds and could expand the boundaries of biosynthesis.

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