Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 558591
Title Obesity affects brain structure and function- rescue by bariatric surgery?
Author(s) Nota, Minke H.C.; Vreeken, Debby; Wiesmann, Maximilian; Aarts, Edo O.; Hazebroek, Eric J.; Kiliaan, Amanda J.
Source Neuroscience and Biobehavioral Reviews 108 (2020). - ISSN 0149-7634 - p. 646 - 657.
DOI https://doi.org/10.1016/j.neubiorev.2019.11.025
Department(s) Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Bariatric surgery - Cognition - Neuroimaging - Obesity
Abstract

Obesity has a major impact on metabolic health thereby negatively affecting brain function and structure, however mechanisms involved are not entirely understood. The increasing prevalence of obesity is accompanied by a growing number of bariatric surgeries (BS). Weight loss after BS appears to improve cognitive function in patients. Therefore, unraveling mechanisms how BS influences brain function may be helpful to develop novel treatments or treatments in combination with BS preventing/inhibiting neurodegenerative disorders like Alzheimer's disease. This review shows the relation between obesity and impaired circulation to and in the brain, brain atrophy, and decreased cognitive functioning. Weight loss seems to recover some of these brain abnormalities as greater white matter and gray matter integrity, functional brain changes and increased cognitive functioning is seen after BS. This relation of body weight and the brain is partly mediated by changes in adipokines, gut hormones and gut microbiota. However, the exact underlying mechanisms remain unknown and further research should be performed.

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