Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 558617
Title Host and Environmental Factors Influencing Individual Human Cytokine Responses
Author(s) Horst, Rob ter; Jaeger, Martin; Smeekens, Sanne P.; Oosting, Marije; Swertz, Morris A.; Li, Yang; Kumar, Vinod; Diavatopoulos, Dimitri A.; Jansen, Anne F.M.; Lemmers, Heidi; Toenhake-Dijkstra, Helga; Herwaarden, Antonius E. van; Janssen, Matthijs; Molen, Renate G. van der; Joosten, Irma; Sweep, Fred C.G.J.; Smit, Johannes W.; Netea-Maier, Romana T.; Koenders, Mieke M.J.F.; Xavier, Ramnik J.; Meer, Jos W.M. van der; Dinarello, Charles A.; Pavelka, Norman; Wijmenga, Cisca; Notebaart, Richard A.; Joosten, Leo A.B.; Netea, Mihai G.
Source Cell 167 (2016)4. - ISSN 0092-8674 - p. 1111 - 1124.e13.
DOI https://doi.org/10.1016/j.cell.2016.10.018
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) age - alpha-1-antitrypsin - cytokines - environment - gender - genetics - host - microbiome - season - vitamin D
Abstract

Differences in susceptibility to immune-mediated diseases are determined by variability in immune responses. In three studies within the Human Functional Genomics Project, we assessed the effect of environmental and non-genetic host factors of the genetic make-up of the host and of the intestinal microbiome on the cytokine responses in humans. We analyzed the association of these factors with circulating mediators and with six cytokines after stimulation with 19 bacterial, fungal, viral, and non-microbial metabolic stimuli in 534 healthy subjects. In this first study, we show a strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators. Additionally, annual seasonality is found to be an important environmental factor influencing cytokine production. Alpha-1-antitrypsin concentrations partially mediate the seasonality of cytokine responses, whereas the effect of vitamin D levels is limited. The complete dataset has been made publicly available as a comprehensive resource for future studies. PaperClip

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