Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 558953
Title MIBiG 2.0: a repository for biosynthetic gene clusters of known function
Author(s) Kautsar, S.A.; Blin, Kai; Shaw, Simon; Navarro Munoz, J.C.; Terlouw, Barbara; Hooft, J.J.J. van der; Santen, Jeffrey A. Van; Tracanna, V.; Suarez Duran, Hernando; Pascal Andreu, V.; Selem Mojica, Nelly; Alanjary, Mohammad; Robinson, Serina; Lund, George; Epstein, Samuel C.; Sisto, Ashley C.; Charkoudian, Louise K.; Collemare, Jérôme; Linington, Roger G.; Weber, Tilmann; Medema, M.H.
Source Nucleic acids research 48 (2020)D1. - ISSN 0305-1048 - p. D454 - D458.
DOI https://doi.org/10.1093/nar/gkz882
Department(s) Bioinformatics
Publication type Refereed Article in a scientific journal
Publication year 2020
Abstract Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites has become a major technology for drug discovery and studying microbiome ecology. In these efforts, computational tools like antiSMASH have played a central role through the analysis of Biosynthetic Gene Clusters (BGCs). Thousands of candidate BGCs from microbial genomes have been identified and stored in public databases. Interpreting the function and novelty of these predicted BGCs requires comparison with a well-documented set of BGCs of known function. The MIBiG (Minimum Information about a Biosynthetic Gene Cluster) Data Standard and Repository was established in 2015 to enable curation and storage of known BGCs. Here, we present MIBiG 2.0, which encompasses major updates to the schema, the data, and the online repository itself. Over the past five years, 851 new BGCs have been added. Additionally, we performed extensive manual data curation of all entries to improve the annotation quality of our repository. We also redesigned the data schema to ensure the compliance of future annotations. Finally, we improved the user experience by adding new features such as query searches and a statistics page, and enabled direct link-outs to chemical structure databases. The repository is accessible online at https://mibig.secondarymetabolites.org/.
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