Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 559042
Title FEMA GRAS assessment of natural flavor complexes : Cinnamomum and Myroxylon-derived flavoring ingredients
Author(s) Rietjens, Ivonne M.C.M.; Cohen, Samuel M.; Eisenbrand, Gerhard; Fukushima, Shoji; Gooderham, Nigel J.; Guengerich, Peter F.; Hecht, Stephen S.; Rosol, Thomas J.; Davidsen, Jeanne M.; Harman, Christie L.; Murray, Ian J.; Taylor, Sean V.
Source Food and Chemical Toxicology 135 (2020). - ISSN 0278-6915
DOI https://doi.org/10.1016/j.fct.2019.110949
Department(s) WIMEK
VLAG
Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Balsam essential oil and extract - Cinnamon and cassia essential oils and extracts - GRAS - Natural flavor complex - Safety evaluation
Abstract

In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, third in the series, considers NFCs composed primarily of constituents with the 3-phenyl-2-propenyl or a cinnamyl functional group, using the procedure outlined in 2005 and updated in 2018 to evaluate the safety of naturally-occurring mixtures for their intended use as flavor ingredients. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of each NFC's chemical constituents into well-defined congeneric groups. The safety of the NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism and toxicology of members of the congeneric groups and the NFC under evaluation. Six NFCs from the Myroxylon and Cinnamomum genera, Balsam Oil, Peru (FEMA 2117), Tolu Balsam Extract (FEMA 3069), Cassia Bark Extract (FEMA 2257), Cassia Bark Oil (FEMA 2258), Cinnamon Bark Extract (FEMA 2290) and Cinnamon Bark Oil (FEMA 2291) were evaluated and affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients.

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