Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560021
Title Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Author(s) Hagenbeek, Fiona A.; Pool, René; Dongen, Jenny van; Draisma, Harmen H.M.; Hottenga, Jouke Jan; Willemsen, Gonneke; Abdellaoui, Abdel; Fedko, Iryna O.; Braber, Anouk den; Visser, Pieter Jelle; Geus, Eco J.C.N. de; Willems van Dijk, Ko; Verhoeven, Aswin; Suchiman, H.E.; Beekman, Marian; Slagboom, Eline P.; Duijn, Cornelia M. van; Barkey Wolf, J.J.H.; Cats, D.; Amin, N.; Beulens, J.W.; Bom, J.A. van der; Bomer, N.; Demirkan, A.; Hilten, J.A. van; Meessen, J.M.T.A.; Moed, M.H.; Fu, J.; Onderwater, G.L.J.; Rutters, F.; So-Osman, C.; Flier, W.M. van der; Heijden, A.A.W.A. van der; Spek, A. van der; Asselbergs, F.W.; Boersma, E.; Elders, P.M.; Geleijnse, J.M.; Ikram, M.A.; Kloppenburg, M.; Meulenbelt, I.; Mooijaart, S.P.; Nelissen, R.G.H.H.; Netea, M.G.; Penninx, B.W.J.H.; Stehouwer, C.D.A.; Teunissen, C.E.; Terwindt, G.M.; Jukema, J.W.; Reinders, M.J.T.
Source Nature Communications 11 (2020)1. - ISSN 2041-1723
DOI https://doi.org/10.1038/s41467-019-13770-6
Department(s) VLAG
Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2020
Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and 52 organic acids. Our study reveals significant differences in h2 Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation have higher h2 Metabolite-hits estimates than phosphatidylcholines with low degrees of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes.

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