Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560040
Title Pyrrolizidine alkaloids in food and phytomedicine : Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review
Author(s) Schrenk, Dieter; Gao, Lan; Lin, Ge; Mahony, Catherine; Mulder, Patrick P.J.; Peijnenburg, Ad; Pfuhler, Stefan; Rietjens, Ivonne M.C.M.; Rutz, Lukas; Steinhoff, Barbara; These, Anja
Source Food and Chemical Toxicology 136 (2020). - ISSN 0278-6915
Department(s) BU Toxicology, Novel Foods & Agrochains
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Food safety - Hepatocarcinogenicity - Liver toxicity - Natural toxins - Pyrrolizidine alkaloids

Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed ‘PAs’) play a distinct role because of the large number of congeners occurring in nature and the pronounced toxicity of some congeners. Several PAs are hepatotoxic in humans, experimental and farm animals and were shown to be potent hepatocarcinogens in laboratory rodents. Although the general mode of action leading to toxicity has been elucidated, i.e., being mediated by metabolic conversion of the parent molecule into a highly reactive electrophile capable of attacking cellular target molecules, major questions related to the risk assessment of PAs remain unresolved. It was the aim of a workshop held in September 2018 to shed more light on the occurrence, exposure, mode of action, toxicokinetics and –dynamics of PAs to improve the scientific basis for an advanced toxicological risk assessment. The contributions in nine chapters describe the scientific progress using advanced analytical methods, studies in subcellular fractions, cell culture, experimental animals and humans and the use of PBPK modeling and structure-activity relationship considerations aiming at a better understanding of PA toxicity and genotoxicity. Since PAs differ considerably in their toxic potencies and substantial species differences in sensitivity towards PA exposure exist, a special emphasis was placed on these issues.

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