Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560237
Title Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
Author(s) Liu, Jun; Lahousse, Lies; Nivard, Michel G.; Bot, Mariska; Chen, Lianmin; Klinken, Jan Bert van; Thesing, Carisha S.; Beekman, Marian; Akker, Erik Ben van den; Slieker, Roderick C.; Waterham, Eveline; Kallen, Carla J.H. van der; Boer, Irene de; Li-Gao, Ruifang; Vojinovic, Dina; Amin, Najaf; Radjabzadeh, Djawad; Kraaij, Robert; Alferink, Louise J.M.; Murad, Sarwa Darwish; Uitterlinden, André G.; Willemsen, Gonneke; Pool, Rene; Milaneschi, Yuri; Heemst, Diana van; Suchiman, H.E.; Rutters, Femke; Elders, Petra J.M.; Beulens, Joline W.J.; Heijden, Amber A.W.A. van der; Greevenbroek, Marleen M.J. van; Arts, Ilja C.W.; Onderwater, Gerrit L.J.; Maagdenberg, Arn M.J.M. van den; Mook-Kanamori, Dennis O.; Hankemeier, Thomas; Terwindt, Gisela M.; Stehouwer, Coen D.A.; Geleijnse, Johanna M.; ‘t Hart, Leen M.; Slagboom, Eline P.; Dijk, Ko Willems van; Zhernakova, Alexandra; Fu, Jingyuan; Penninx, Brenda W.J.H.; Boomsma, Dorret I.; Demirkan, Ayşe; Stricker, Bruno H.C.; Duijn, Cornelia M. van
Source Nature Medicine 26 (2020)1. - ISSN 1078-8956 - p. 110 - 117.
DOI https://doi.org/10.1038/s41591-019-0722-x
Department(s) Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2020
Abstract

Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 drug–metabolite associations after evaluation of confounders including co-treatment. We show that the effect estimates of statins on metabolites from the cross-sectional study are comparable to those from intervention and genetic observational studies. Further data integration links proton pump inhibitors to circulating metabolites, liver function, hepatic steatosis and the gut microbiome. Our atlas provides a tool for targeted experimental pharmaceutical research and clinical trials to improve drug efficacy, safety and repurposing. We provide a web-based resource for visualization of the atlas (http://bbmri.researchlumc.nl/atlas/).

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