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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560431
Title Genomic selection without own phenotypes exploits new mutational variance less than BLUP selection
Author(s) Mulder, H.A.; Lee, S.H.; Clark, Sam; Hayes, B.; Werf, Julius H.J. van der
Source In: Book of Abstracts of the 70th Annual Meeting of the European Federation of Animal Science. - Wageningen : Wageningen Academic Publishers (Book of Abstracts ) - ISBN 9789086863396 - p. 123 - 123.
Event Wageningen : Wageningen Academic Publishers (Book of Abstracts ) - ISBN 9789086863396 70th Annual Meeting of the European Federation of Animal Science, 2019-08-25/2019-08-31
Department(s) WIAS
Animal Breeding and Genomics
Publication type Abstract in scientific journal or proceedings
Publication year 2019
Abstract De novo mutations (DNM) create new genetic variance and are an important driver for long-term selection response. We hypothesized that genomic selection without own phenotypes exploits new mutational variance less than pedigree-based BLUP selection. The objectives were to compare GBLUP selection without own phenotype (GBLUP), GBLUP selection with own phenotype (GBLUP_OP) and pedigree-based BLUP selection with own phenotype for 20 generations using Monte Carlo simulation. GBLUP resulted in the lowest genetic variance (24.7%
of total genetic variance) and response due to DNM after 20 generations (9.4% of total response). GBLUP_OP had the highest genetic variance due to new DNM (47.8% of total genetic variance) and selection response due to DNM
(30% of total response), while BLUP was in between with 27.1% of genetic variance due to DNM and 21.9% of response due to DNM. However, GBLUP_OP caused a rapid decline in total genetic variance, because the genetic
variance due to old QTL rapidly eroded. GBLUP had very little selection pressure on DNM and as a consequence, GBLUP had the highest number of DNM with negative effects that were still segregating 10 generations after a
DNM arose. Due to the decline in genetic variance for all selection strategies, selection limits are foreseen and these selection limits are lower for GBLUP (11.2 phenotypic SD from the base population mean) and GBLUP_OP (10.7
phenotypic SD) than for BLUP selection (11.8 phenotypic SD). It can be concluded that genomic selection without own phenotypes exploits new mutational variance less than BLUP selection with own phenotypes, it increases the
probability of DNM with negative effects and it lowers selection limits. Sustainable breeding strategies should consider optimal ways to exploit DNM.
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