Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560493
Title Evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels
Author(s) Schrenk, Dieter; Bignami, Margherita; Bodin, Laurent; Chipman, James Kevin; Mazo, Jesús del; Grasl-Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius; Leblanc, Jean Charles; Nebbia, Carlo Stefano; Nielsen, Elsa; Ntzani, Evangelia; Petersen, Annette; Sand, Salomon; Vleminckx, Christiane; Wallace, Heather; Benford, Diane; Brimer, Leon; Mancini, Francesca Romana; Metzler, Manfred; Viviani, Barbara; Altieri, Andrea; Arcella, Davide; Steinkellner, Hans; Schwerdtle, Tanja
Source EFSA Journal 17 (2019)4. - ISSN 1831-4732
DOI https://doi.org/10.2903/j.efsa.2019.5662
Department(s) BU Toxicology, Novel Foods & Agrochains
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) cyanide - cyanogenic glycosides - health-based guidance values - risk assessment
Abstract

In 2016, the EFSA Panel on Contaminants in the Food Chain (CONTAM) published a scientific opinion on the acute health risks related to the presence of cyanogenic glycosides (CNGs) in raw apricot kernels in which an acute reference dose (ARfD) of 20 μg/kg body weight (bw) was established for cyanide (CN). In the present opinion, the CONTAM Panel concluded that this ARfD is applicable for acute effects of CN regardless the dietary source. To account for differences in cyanide bioavailability after ingestion of certain food items, specific factors were used. Estimated mean acute dietary exposures to cyanide from foods containing CNGs did not exceed the ARfD in any age group. At the 95th percentile, the ARfD was exceeded up to about 2.5-fold in some surveys for children and adolescent age groups. The main contributors to exposures were biscuits, juice or nectar and pastries and cakes that could potentially contain CNGs. Taking into account the conservatism in the exposure assessment and in derivation of the ARfD, it is unlikely that this estimated exceedance would result in adverse effects. The limited data from animal and human studies do not allow the derivation of a chronic health-based guidance value (HBGV) for cyanide, and thus, chronic risks could not be assessed.

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