Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560841
Title Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency
Author(s) Mierlo, Guido van; Dirks, René A.M.; Clerck, Laura De; Brinkman, Arie B.; Huth, Michelle; Kloet, Susan L.; Saksouk, Nehmé; Kroeze, Leonie I.; Willems, Sander; Farlik, Matthias; Bock, Christoph; Jansen, Joop H.; Deforce, Dieter; Vermeulen, Michiel; Déjardin, Jérôme; Dhaenens, Maarten; Marks, Hendrik
Source Cell Stem Cell 24 (2019)1. - ISSN 1934-5909 - p. 123 - 137.e8.
DOI https://doi.org/10.1016/j.stem.2018.10.017
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) chromatin profiling - embryonic stem cells - epigenetics - ground-state pluripotency - H3K27me3 - histone modifications
Abstract

Marks and colleagues use integrative mass spectrometry to profile post-translational histone modifications and the chromatin-associated proteome in ground-state pluripotency. This reveals H3K27me3 and PRC2 as widespread hallmarks on euchromatin and heterochromatin. They show that ubiquitous chromatin-associated PRC2 protects the epigenome from priming, in particular from gaining DNA methylation.

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