Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560876
Title Regulation and activation of SOBIR1-containing receptor complexes involved in plant immune signalling
Author(s) Wu, Jinbin
Source Wageningen University. Promotor(en): B.P.H.J. Thomma, co-promotor(en): M.H.A.J. Joosten. - Wageningen : Wageningen University - ISBN 9789463951821 - 183
Department(s) Laboratory of Phytopathology
Publication type Dissertation, internally prepared
Publication year 2020
Availibility Full text available from 2021-02-03

The tomato cell surface receptor-like protein (RLP) Cf-4 confers resistance to Avr4-secreting strains of the fungus Cladosporium fulvum, which causes tomato leaf mould disease. Cf-4 constitutively interacts with the receptor-like kinase (RLK) SOBIR1 and interacts with the RLK BAK1 upon recognition of Avr4 by Cf-4. Formation of the Cf-4/SOBIR1/BAK1 complex is proposed to trigger phosphorylation of the intracellular kinase domains of SOBIR1 and BAK1, which subsequently activate downstream signalling resulting in plant immunity. However, components involved in regulating the Avr4-induced formation and subsequent activation of the Cf-4/SOBIR1/BAK1 complex remain unknown. In addition, downstream components required for Cf-4 signalling are largely unknown. The work described in this thesis is aimed at gaining more insight into the molecular mechanisms of Cf-4 signalling. Furthermore, the application of the gained knowledge to genetically engineer plant immunity is pursued. Additionally, as SOBIR1, which is functionally required for all RLPs mediating immunity, also interacts with the RLP CLAVATA2 (CLV2) involved in development, the significance of the CLV2/SOBIR1 complex is investigated.

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