Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 560930
Title Hox genes polymorphism depicts developmental disruption of common sole eggs
Author(s) Kavouras, Menelaos; Malandrakis, Emmanouil E.; Danis, Theodoros; Blom, Ewout; Anastassiadis, Konstantinos; Panagiotaki, Panagiota; Exadactylos, Athanasios
Source Open Life Sciences 14 (2019)1. - ISSN 2391-5412 - p. 549 - 563.
Department(s) Onderz. Form. I.
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) egg quality - embryonic development - Hox genes - polymorphism - reproduction

In sole aquaculture production, consistency in the quality of produced eggs throughout the year is unpredictable. Hox genes have a crucial role in controlling embryonic development and their genetic variation could alter the phenotype dramatically. In teleosts genome duplication led paralog hox genes to become diverged. Direct association of polymorphism in hoxa1a, hoxa2a & hoxa2b of Solea solea with egg viability indicates hoxa2b as a potential genetic marker. High Resolution Melt (HRM) analysis was carried out in 52 viable and 61 non-viable eggs collected at 54±6 hours post fertilization (hpf). Allelic and genotypic frequencies of polymorphism were analyzed and results illustrated a significantly increased risk for non-viability for minor alleles and their homozygous genotypes. Haplotype analysis demonstrated a significant recessive effect on the risk of non-viability, by increasing the odds of disrupting embryonic development up to three-fold. Phylogenetic analysis showed that the paralog genes hoxa2a and hoxa2b, are separated distinctly in two clades and presented a significant ω variation, revealing their diverged evolutionary rate.

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