Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 561137
Title Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems
Author(s) Patterson, Adrian G.; Jackson, Simon A.; Taylor, Corinda; Evans, Gary B.; Salmond, George P.C.; Przybilski, Rita; Staals, Raymond H.J.; Fineran, Peter C.
Source Molecular Cell 64 (2016)6. - ISSN 1097-2765 - p. 1102 - 1108.
DOI https://doi.org/10.1016/j.molcel.2016.11.012
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) bacterial communication - CRISPR-Cas - horizontal gene transfer - phage resistance - quorum sensing - regulation
Abstract

Bacteria commonly exist in high cell density populations, making them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugation. To combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunity. Many bacterial populations coordinate their behavior as cell density increases, using quorum sensing (QS) signaling. In this study, we demonstrate that QS regulation results in increased expression of the type I-E, I-F, and III-A CRISPR-Cas systems in Serratia cells in high-density populations. Strains unable to communicate via QS were less effective at defending against invaders targeted by any of the three CRISPR-Cas systems. Additionally, the acquisition of immunity by the type I-E and I-F systems was impaired in the absence of QS signaling. We propose that bacteria can use chemical communication to modulate the balance between community-level defense requirements in high cell density populations and host fitness costs of basal CRISPR-Cas activity.

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