Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 561414
Title Low-field benchtop NMR spectroscopy: status and prospects in natural product analysis
Author(s) Beek, Teris André van
Source Phytochemical Analysis (2020). - ISSN 0958-0344
DOI https://doi.org/10.1002/pca.2921
Department(s) VLAG
Organic Chemistry
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) adulteration - benchtop analysis - education - forensics - low-field NMR - quality control
Abstract

Introduction: Since a couple of years, low-field (LF) nuclear magnetic resonance (NMR) spectrometers (40–100 MHz) have re-entered the market. They are used for various purposes including analyses of natural products. Similar to high-field instruments (300–1200 MHz), modern LF instruments can measure multiple nuclei and record two-dimensional (2D) NMR spectra. Objective: To review the commercial availability as well as applications, advantages, limitations, and prospects of LF-NMR spectrometers for the purpose of natural products analysis. Method: Commercial LF instruments were compared. A literature search was performed for articles using and discussing modern LF-NMR. Next, the articles relevant to natural products were read and summarised. Results: Seventy articles were reviewed. Most appeared in 2018 and 2019. Low costs and ease of operation are most often mentioned as reasons for using LF-NMR. Conclusion: As the spectral resolution of LF instruments is limited, they are not used for structure elucidation of new natural products but rather applied for quality control (QC), forensics, food and health research, process control and teaching. Chemometric data handling is valuable. LF-NMR is a rapidly developing niche and new instruments keep being introduced.

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