Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 561668
Title Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?
Author(s) Bekkering, Siroon; Saner, Christoph; Riksen, Niels P.; Netea, Mihai G.; Sabin, Matthew A.; Saffery, Richard; Stienstra, Rinke; Burgner, David P.
Source Trends in Endocrinology & Metabolism (2020). - ISSN 1043-2760
DOI https://doi.org/10.1016/j.tem.2020.01.008
Department(s) Nutrition, Metabolism and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) atherosclerosis - cardiovascular disease - inflammation - obesity - trained immunity
Abstract

Obesity, a chronic inflammatory disease, is the most prevalent modifiable risk factor for cardiovascular disease. The mechanisms underlying inflammation in obesity are incompletely understood. Recent developments have challenged the dogma of immunological memory occurring exclusively in the adaptive immune system and show that the innate immune system has potential to be reprogrammed. This innate immune memory (trained immunity) is characterized by epigenetic and metabolic reprogramming of myeloid cells following endogenous or exogenous stimulation, resulting in enhanced inflammation to subsequent stimuli. Trained immunity phenotypes have now been reported for other immune and non-immune cells. Here, we provide a novel perspective on the putative role of trained immunity in mediating the adverse cardiovascular effects of obesity and highlight potential translational pathways.

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