|Title||One-carbon metabolites, B-vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: Results from the ColoCare Study|
|Author(s)||Kiblawi, Rama; Holowatyj, Andreana N.; Gigic, Biljana; Brezina, Stefanie; Geijsen, Anne J.M.R.; Ose, Jennifer; Lin, Tengda; Hardikar, Sheetal; Himbert, Caroline; Warby, Christy A.; Böhm, Jürgen; Bours, Martijn J.L.; Duijnhoven, Fränzel J.B. Van; Gumpenberger, Tanja; Kok, Dieuwertje E.; Koole, Janna L.; Roekel, Eline H. Van; Schrotz-King, Petra; Ulvik, Arve; Gsur, Andrea; Habermann, Nina; Weijenberg, Matty P.; Ueland, Per Magne; Schneider, Martin; Ulrich, Alexis; Ulrich, Cornelia M.; Playdon, Mary|
|Source||The British journal of nutrition (2020). - ISSN 0007-1145|
|Department(s)||Nutrition and Disease|
|Publication type||Refereed Article in a scientific journal|
|Keyword(s)||B-vitamins - colorectal cancer - CRPangiogenesis - folate - folic acid - inflammation - One-carbon metabolism - Vitamin B|
B-vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- A nd angiogenesis-related chronic diseases, such as colorectal cancer. Yet, the role of one-carbon metabolism in inflammation and angiogenesis among colorectal cancer patients remains unclear.The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed colorectal cancer patients (n=238) in the prospective ColoCare Study, Heidelberg.We cross-sectionally analyzed associations between 12 B-vitamins and one-carbon metabolites and 10 inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesized that pyridoxal-5'-phosphate (PLP) is inversely associated with inflammatory biomarkers.We observed that PLP was inversely associated with CRP (r=-0.33, plinear<0.0001), SAA (r=-0.23, plinear=0.003), IL-6 (r=-0.39, plinear <0.0001), IL-8 (r=-0.20, plinear=0.02) and TNFα (r=-0.12, plinear=0.045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r=-0.14), SAA (r=-0.14) and TNFα (r=-0.15) among colorectal cancer patients. Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear<0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear<0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for colorectal cancer patients.