Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 561919
Title The MCRA toolbox of models and data to support chemical mixture risk assessment
Author(s) Voet, Hilko van der; Kruisselbrink, Johannes W.; Boer, Waldo J. de; Lenthe, Marco S. van; Heuvel, J.J.B. van den; Crépet, Amélie; Kennedy, Marc C.; Zilliacus, Johanna; Beronius, Anna; Tebby, Cleo; Brochot, Céline; Luckert, Claudia; Lampen, Alfonso; Rorije, Emiel; Sprong, Corinne; Klaveren, Jacob D. van
Source Food and Chemical Toxicology 138 (2020). - ISSN 0278-6915
DOI https://doi.org/10.1016/j.fct.2020.111185
Department(s) Biometris
Mathematical and Statistical Methods - Biometris
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Exposure - Hazard - Mixtures - Probabilistic model - Risk assessment - Software
Abstract

A model and data toolbox is presented to assess risks from combined exposure to multiple chemicals using probabilistic methods. The Monte Carlo Risk Assessment (MCRA) toolbox, also known as the EuroMix toolbox, has more than 40 modules addressing all areas of risk assessment, and includes a data repository with data collected in the EuroMix project. This paper gives an introduction to the toolbox and illustrates its use with examples from the EuroMix project. The toolbox can be used for hazard identification, hazard characterisation, exposure assessment and risk characterisation. Examples for hazard identification are selection of substances relevant for a specific adverse outcome based on adverse outcome pathways and QSAR models. Examples for hazard characterisation are calculation of benchmark doses and relative potency factors with uncertainty from dose response data, and use of kinetic models to perform in vitro to in vivo extrapolation. Examples for exposure assessment are assessing cumulative exposure at external or internal level, where the latter option is needed when dietary and non-dietary routes have to be aggregated. Finally, risk characterisation is illustrated by calculation and display of the margin of exposure for single substances and for the cumulation, including uncertainties derived from exposure and hazard characterisation estimates.

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