Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562096
Title Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits
Author(s) Viitaniemi, Heidi M.; Verhagen, Irene; Visser, Marcel E.; Honkela, Antti; Oers, Kees van; Husby, Arild
Source Genome Biology and Evolution 11 (2019)3. - ISSN 1759-6653 - p. 970 - 983.
DOI https://doi.org/10.1093/gbe/evz044
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) DNA methylation - epigenetics - laying date. - Parus major - RRBS - timing of reproduction
Abstract

In seasonal environments, timing of reproduction is a traitwith important fitness consequences, butwe know little about the molecular mechanisms that underlie the variation in this trait. Recently, several studies put forward DNA methylation as a mechanism regulating seasonal timing of reproduction in both plants and animals. To understand the involvement of DNA methylation in seasonal timing of reproduction, it is necessary to examine within-individual temporal changes in DNA methylation, but such studies are very rare. Here, we use a temporal sampling approach to examine changes in DNA methylation throughout the breeding season in female great tits (Parus major) that were artificially selected for early timing of breeding. These females were housed in climate-controlled aviaries and subjected to two contrasting temperature treatments. Reduced representation bisulfite sequencing on red blood cell derived DNA showed genome-wide temporal changes inmore than 40,000 out of the 522,643 CpG sites examined. Althoughmost of these changeswere relatively small (mean within-individual change of 6%), the sites that showed a temporal and treatment-specific response in DNA methylation are candidate sites of interest for future studies trying to understand the link between DNAmethylation patterns and timing of reproduction.

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