Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562116
Title The use of adverse outcome pathways in the safety evaluation of food additives
Author(s) Vinken, Mathieu; Kramer, Nynke; Allen, Timothy E.H.; Hoffmans, Yvette; Thatcher, Natalie; Levorato, Sara; Traussnig, Heinz; Schulte, Stefan; Boobis, Alan; Thiel, Anette; Rietjens, Ivonne M.C.M.
Source Archives of Toxicology 94 (2020). - ISSN 0340-5761
DOI https://doi.org/10.1007/s00204-020-02670-0
Department(s) BU Toxicology, Novel Foods & Agrochains
WIMEK
VLAG
Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Adverse outcome pathway - Food additive - Safety evaluation
Abstract

In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and cosmetics sectors has been well documented, their application in the food area remains largely unexplored. In this respect, an expert group of the International Life Sciences Institute Europe has recently explored the use of adverse outcome pathways in the safety evaluation of food additives. A key activity was the organization of a workshop, gathering delegates from the regulatory, industrial and academic areas, to discuss the potentials and challenges related to the application of adverse outcome pathways in the safety assessment of food additives. The present paper describes the outcome of this workshop followed by a number of critical considerations and perspectives defined by the International Life Sciences Institute Europe expert group.

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