Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562201
Title A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data
Author(s) O’Donovan, Shauna D.; Lenz, Michael; Vink, Roel G.; Roumans, Nadia J.T.; Kok, Theo M.C.M. de; Mariman, Edwin C.M.; Peeters, Ralf L.M.; Riel, Natal A.W. van; Baak, Marleen A. van; Arts, Ilja C.W.
Source PLoS Computational Biology 15 (2019)10. - ISSN 1553-734X
DOI https://doi.org/10.1371/journal.pcbi.1007400
Department(s) Nutrition, Metabolism and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

Given the association of disturbances in non-esterified fatty acid (NEFA) metabolism with the development of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease, computational models of glucose-insulin dynamics have been extended to account for the interplay with NEFA. In this study, we use arteriovenous measurement across the subcutaneous adipose tissue during a mixed meal challenge test to evaluate the performance and underlying assumptions of three existing models of adipose tissue metabolism and construct a new, refined model of adipose tissue metabolism. Our model introduces new terms, explicitly accounting for the conversion of glucose to glyceraldehye-3-phosphate, the postprandial influx of glycerol into the adipose tissue, and several physiologically relevant delays in insulin signalling in order to better describe the measured adipose tissues fluxes. We then applied our refined model to human adipose tissue flux data collected before and after a diet intervention as part of the Yoyo study, to quantify the effects of caloric restriction on postprandial adipose tissue metabolism. Significant increases were observed in the model parameters describing the rate of uptake and release of both glycerol and NEFA. Additionally, decreases in the model’s delay in insulin signalling parameters indicates there is an improvement in adipose tissue insulin sensitivity following caloric restriction.

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