Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562273
Title A retain and refine approach to cumulative risk assessment
Author(s) Kennedy, Marc C.; Hart, Andy D.M.; Kruisselbrink, Johannes W.; Lenthe, Marco van; Boer, Waldo J. de; Voet, Hilko van der; Rorije, Emiel; Sprong, Corinne; Klaveren, Jacob van
Source Food and Chemical Toxicology 138 (2020). - ISSN 0278-6915
DOI https://doi.org/10.1016/j.fct.2020.111223
Department(s) Biometris
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Cumulative assessment group - Mixtures - Pesticides - QSAR - Relative potency factor - Uncertainty
Abstract

Mixtures of substances to which humans are exposed may lead to cumulative exposure and health effects. To study their effects, it is first necessary to identify a cumulative assessment group (CAG) of substances for risk assessment or hazard testing. Excluding substances from consideration before there is sufficient evidence may underestimate the risk. Conversely, including everything and treating the inevitable uncertainties using conservative assumptions is inefficient and may overestimate the risk, with an unknown level of protection. An efficient, transparent strategy is described to retain a large group, quantifying the uncertainty of group membership and other uncertainties. Iterative refinement of the CAG then focuses on adding information for the substances with high probability of contributing significantly to the risk. Probabilities can be estimated using expert opinion or derived from data on substance properties. An example is presented with 100 pesticides, in which the retain step identified a single substance to target refinement. Using an updated hazard characterisation for this substance reduced the mean exposure estimate from 0.43 to 0.28 μg kg-bw−1 day−1 and reduced the 99.99th percentile exposure from 24.9 to 5.1 μg kg-bw−1 day−1. Other retained substances contributed little to the risk estimates, even after accounting for uncertainty.

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