Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562286
Title Altered hippocampal epigenetic regulation underlying reduced cognitive development in response to early life environmental insults
Author(s) Schachtschneider, Kyle M.; Welge, Michael E.; Auvil, Loretta S.; Chaki, Sulalita; Rund, Laurie A.; Madsen, Ole; Elmore, Monica R.P.; Johnson, Rodney W.; Groenen, Martien A.M.; Schook, Lawrence B.
Source Genes 11 (2020)2. - ISSN 2073-4425
DOI https://doi.org/10.3390/genes11020162
Department(s) WIAS
Animal Breeding and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Cognitive development - DNA methylation - Hippocampus - Machine learning - Porcine biomedical models - RNA-seq
Abstract

The hippocampus is involved in learning and memory and undergoes significant growth and maturation during the neonatal period. Environmental insults during this developmental timeframe can have lasting effects on brain structure and function. This study assessed hippocampal DNA methylation and gene transcription from two independent studies reporting reduced cognitive development stemming from early life environmental insults (iron deficiency and porcine reproductive and respiratory syndrome virus (PRRSv) infection) using porcine biomedical models. In total, 420 differentially expressed genes (DEGs) were identified between the reduced cognition and control groups, including genes involved in neurodevelopment and function. Gene ontology (GO) terms enriched for DEGs were associated with immune responses, angiogenesis, and cellular development. In addition, 116 differentially methylated regions (DMRs) were identified, which overlapped 125 genes. While no GO terms were enriched for genes overlapping DMRs, many of these genes are known to be involved in neurodevelopment and function, angiogenesis, and immunity. The observed altered methylation and expression of genes involved in neurological function suggest reduced cognition in response to early life environmental insults is due to altered cholinergic signaling and calcium regulation. Finally, two DMRs overlapped with two DEGs, VWF and LRRC32, which are associated with blood brain barrier permeability and regulatory T-cell activation, respectively. These results support the role of altered hippocampal DNA methylation and gene expression in early life environmentally-induced reductions in cognitive development across independent studies.

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