Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562419
Title Highly sensitive integrated optical biosensing platform based on an asymmetric Mach-Zehnder interferometer and material-selective (bio)functionalization
Author(s) Knoben, W.; Besselink, G.; Roeven, E.; Zuilhof, H.; Schütz-Trilling, A.; Meer, A. van der; Scheres, L.; Leeuwis, H.; Falke, F.; Schreuder, F.; Heideman, R.; Vlekkert, H. van den
Source In: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. - Chemical and Biological Microsystems Society (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 ) - ISBN 9781510897571 - p. 982 - 985.
Event 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, 2018-11-11/2018-11-15
Department(s) Organic Chemistry
VLAG
Publication type Contribution in proceedings
Publication year 2018
Keyword(s) Integrated optics - Optical detection - Surface modification
Abstract

An innovative integrated optical biosensing platform with an extremely high sensitivity is presented. The platform uses TriPleX (Si3N4/SiO2) waveguide technology in an asymmetric Mach-Zehnder Interferometer (aMZI) configuration, which is intrinsically more sensitive than other waveguide-based sensor technologies and Surface Plasmon Resonance (SPR). The performance of the sensor is enhanced by material-selective functionalization of Si3N4 vs. SiO2, allowing site-selective immobilization of the bioreceptor to the waveguide surface. The rest of the chip surface is modified with an antifouling layer to reduce non-specific adsorption. Analyte binding is thus confined to the waveguide surface, which results in improved sensitivity and limit of detection.

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