Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562430
Title Micro magnetic resonance imaging of murine liver tissue slices on a microfluidic perfusion device
Author(s) Sharma, Manvendra; Patra, Bishnubrata; Hale, William; Karsten, Ruby E.H.; Salentijn, Gert I.J.; Grajewski, Maciej; Fuhrer, Erwin; Zakhurdaeva, Anna; Mager, Dario; Korvink, Jan; Olinga, Peter; Verpoorte, Elisabeth; Utz, Marcel
Source In: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. - Chemical and Biological Microsystems Society (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 ) - ISBN 9781510897571 - p. 1722 - 1724.
Event 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, 2018-11-11/2018-11-15
Department(s) Organic Chemistry
Publication type Contribution in proceedings
Publication year 2018
Keyword(s) Micro-MRI - NMR - PCLS
Abstract

Micro-MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) spectroscopy are used to image and study metabolic activity of precision-cut liver slices (PCLS) on a microfluidic perfusion device. The imaging experiments were performed under static medium conditions while metabolic activity was monitored under continuous flow of medium. LDH (Lactate dehydrogenase) leakage assay was performed to assess the tissue viability on different days. MR images having ~30 (μm)2 in-plane resolution are recorded. This method could be used to culture and monitor PCLS non-invasively.

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