Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562700
Title Deep mitochondrial origin outside the sampled alphaproteobacteria
Author(s) Martijn, Joran; Vosseberg, Julian; Guy, Lionel; Offre, Pierre; Ettema, Thijs J.G.
Source Nature 557 (2018)7703. - ISSN 0028-0836 - p. 101 - 105.
DOI https://doi.org/10.1038/s41586-018-0059-5
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Mitochondria are ATP-generating organelles, the endosymbiotic origin of which was a key event in the evolution of eukaryotic cells 1 . Despite strong phylogenetic evidence that mitochondria had an alphaproteobacterial ancestry 2, efforts to pinpoint their closest relatives among sampled alphaproteobacteria have generated conflicting results, complicating detailed inferences about the identity and nature of the mitochondrial ancestor. While most studies support the idea that mitochondria evolved from an ancestor related to Rickettsiales 3-9, an order that includes several host-Associated pathogenic and endosymbiotic lineages 10,11, others have suggested that mitochondria evolved from a free-living group 12-14 . Here we re-evaluate the phylogenetic placement of mitochondria. We used genome-resolved binning of oceanic metagenome datasets and increased the genomic sampling of Alphaproteobacteria with twelve divergent clades, and one clade representing a sister group to all Alphaproteobacteria. Subsequent phylogenomic analyses that specifically address long branch attraction and compositional bias artefacts suggest that mitochondria did not evolve from Rickettsiales or any other currently recognized alphaproteobacterial lineage. Rather, our analyses indicate that mitochondria evolved from a proteobacterial lineage that branched off before the divergence of all sampled alphaproteobacteria. In light of this new result, previous hypotheses on the nature of the mitochondrial ancestor 6,15,16 should be re-evaluated.

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