Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562714
Title The Impact of Non-additive Effects on the Genetic Correlation Between Populations
Author(s) Duenk, P.; Bijma, P.; Calus, M.P.L.; Wientjes, Y.C.J.; Werf, Julius van der
Source G3 : Genes Genomes Genetics 10 (2020)2. - ISSN 2160-1836 - p. 783 - 795.
DOI https://doi.org/10.1534/g3.119.400663
Department(s) WIAS
Animal Breeding and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2020
Abstract Average effects of alleles can show considerable differences between populations. The magnitude of these differences can be measured by the additive genetic correlation between populations ([Formula: see text]). This [Formula: see text] can be lower than one due to the presence of non-additive genetic effects together with differences in allele frequencies between populations. However, the relationship between the nature of non-additive effects, differences in allele frequencies, and the value of [Formula: see text] remains unclear, and was therefore the focus of this study. We simulated genotype data of two populations that have diverged under drift only, or under drift and selection, and we simulated traits where the genetic model and magnitude of non-additive effects were varied. Results showed that larger differences in allele frequencies and larger non-additive effects resulted in lower values of [Formula: see text] In addition, we found that with epistasis, [Formula: see text] decreases with an increase of the number of interactions per locus. For both dominance and epistasis, we found that, when non-additive effects became extremely large, [Formula: see text] had a lower bound that was determined by the type of inter-allelic interaction, and the difference in allele frequencies between populations. Given that dominance variance is usually small, our results show that it is unlikely that true [Formula: see text] values lower than 0.80 are due to dominance effects alone. With realistic levels of epistasis, [Formula: see text] dropped as low as 0.45. These results may contribute to the understanding of differences in genetic expression of complex traits between populations, and may help in explaining the inefficiency of genomic trait prediction across populations.
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