Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562719
Title The tonsillar microbiome of Streptococcus suis diseased piglets
Author(s) Fredriksen, Simen; Neila, Carlos; Fernandes de Oliveira, Isabela; Murray, G.; Guan, X.; Ferrando, M.L.; Correa-Fiz, Flor; Baarlen, P. van; Aragon, Virginia; Wells, J.M.
Source In: WIAS Annual Conference 2020. - WIAS - p. 22 - 22.
Event WIAS Annual Conference 2020, Lunteren, 2020-02-13/2020-02-14
Department(s) Host-Microbe Interactomics
WIAS
VLAG
Publication type Abstract in scientific journal or proceedings
Publication year 2020
Abstract microbiome is important in shaping the host immune system as well as providing direct protection against pathogens by colonization resistance. Streptococcus suis is one of the most abundant bacteria in the oral cavity of pigs, but also a zoonotic pathogen of increasing importance. S. suis is a complex pathogen with a large diversity of pathogenic and commensal strains, and there is no cross protective vaccine. Pathogenic strains are hypothesized to enter the host via the palatine tonsils, a lymphoid organ colonized by S. suisin virtually all pigs. In order to enter the host bloodstream via the tonsils, pathogenic S. suis strains first need to colonize the tonsillar biofilm. It is possible that this is facilitated during microbial dysbiosis when there is reduced competition from commensal bacteria. We have utilized both amplic on and shotgun sequencing approaches to quantify the tonsillar microbiome of S. suis diseased piglets and healthy controls. We find microbiome compositionand diversity to differ between controls and symptomatic animals, even weeks before disease occurrence. The tonsils of symptomatic animals also contain a higher relative abundance of genes that are conserved in disease-associated S. suis strains but lacking in commensals. Moreover, we find non-symptomatic litter mates of diseased piglets to have an intermediate microbiome profile. We hypothesize that some sows provide piglets with a disease-prone microbiome, possibly due to direct transmission of an unhealthy microbiome or deficient colostrum. Within our consortium we are utilizing the results from this study in vaccine and probiotics development.
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