Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 562805
Title Preliminary characterization of IgT1 and IgT2 immunoglobulin isotypes in systemic and mucosal tissues in carp
Author(s) Awatif, Eltijani; Brugman, S.; Wiegertjes, G.; Forlenza, M.
Source In: Wias Annual Conference 2020. - WIAS - p. 56 - 56.
Event WIAS Annual Conference 2020, Lunteren, 2020-02-13/2020-02-14
Department(s) Cell Biology and Immunology
Aquaculture and Fisheries
Infection Biology
Publication type Abstract in scientific journal or proceedings
Publication year 2020
Abstract The main components of humoral immune response in fish are IgM, IgD and IgT immunoglobulins. IgT was described initially as an immunoglobulin responsible for immune respons eat mucosal surfaces. However, currently it is known to play a role in both systemic and mucosal compartments. So far, two variants of IgT (IgT1 and IgT2) have been described in common carp. However, due to the lack of specific tools, no functional studies have been conducted on IgT in carp. In this study, we describe the generation and validation of IgT1and IgT2-specific tools and provide a preliminary characterization of the tissue distribution of IgT1+ and IgT2+ B cells, as well as of the abundance of soluble IgT1 and IgT2 in mucosal and systemic tissues of naïve and infected carp. In this poster, we will give preliminary characterization of IgT1 and IgT2 immunoglobulin isotypes and show that IgT1, similarly to IgMis preferentially expressed and responds to systemic stimuli, whereas IgT2 is preferentially present in mucosal tissues of carp.
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