Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 563804
Title Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes
Author(s) Zhou, Zhangsen; Torres, Mauricio; Sha, Haibo; Halbrook, Christopher J.; Bergh, Françoise van den; Reinert, Rachel B.; Yamada, Tatsuya; Wang, Siwen; Luo, Yingying; Hunter, Allen H.; Wang, Chunqing; Sanderson, Thomas H.; Liu, Meilian; Taylor, Aaron; Sesaki, Hiromi; Lyssiotis, Costas A.; Wu, Jun; Kersten, Sander; Beard, Daniel A.; Qi, Ling
Source Science 368 (2020)6486. - ISSN 0036-8075 - p. 54 - 60.
DOI https://doi.org/10.1126/science.aay2494
Department(s) VLAG
Nutrition, Metabolism and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2020
Abstract

The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD.

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