Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 565789
Title The association between circulating levels of vitamin D and inflammatory markers in the first 2 years after colorectal cancer diagnosis
Author(s) Wesselink, Evertine; Balvers, Michiel; Bours, Martijn J.L.; Wilt, Johannes H.W. de; Witkamp, Renger F.; Baar, Harm van; Geijsen, Anne J.M.R.; Halteren, Henk van; Keulen, Eric T.P.; Kok, Dieuwertje E.; Kouwenhoven, Ewout A.; Ouweland, Jody van den; Zutphen, Moniek van; Weijenberg, Matty P.; Kampman, Ellen; Duijnhoven, Fränzel J.B. van
Source Therapeutic Advances in Gastroenterology 13 (2020). - ISSN 1756-283X
DOI https://doi.org/10.1177/1756284820923922
Department(s) Nutrition and Disease
HNRU&LB
VLAG
Nutritional Biology and Health
Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) 25(OH)D - colorectal cancer - cytokines - inflammatory markers - interleukin 6
Abstract

Background: Calcitriol, the active form of vitamin D, may inhibit colorectal cancer (CRC) progression, which has been mechanistically linked to an attenuation of a pro-inflammatory state. The present study investigated the associations between circulating 25 hydroxy vitamin D3 (25(OH)D3) levels and inflammatory markers (IL10, IL8, IL6, TNFα and hsCRP) in the 2 years following CRC diagnosis. Methods: Circulating 25(OH)D3 levels and inflammatory markers were assessed at diagnosis, after 6, 12 and 24 months from 798 patients with sporadic CRC participating in two prospective cohort studies. Associations between 25(OH)D3 levels and individual inflammatory markers as well as a summary inflammatory z-score were assessed at each time point by multiple linear regression analyses. To assess the association between 25(OH)D3 and inflammatory markers over the course of 2 years, linear mixed model regression analyses were conducted. Results: Higher 25(OH)D3 levels were associated with lower IL6 levels at diagnosis, at 6 months after diagnosis and over the course of 2 years (β −0.06, 95% CI −0.08 to −0.04). In addition, 25(OH)D3 levels were inversely associated with the summary inflammatory z-score at diagnosis and over the course of 2 years (β −0.17, 95% CI −0.25 to −0.08). In addition, a significant inverse association between 25(OH)D3 levels and IL10 was found over the course of 2 years. Intra-individual analyses showed an inverse association between 25(OH)D3 and IL10, IL6 and TNFα. No statistically significant associations between 25(OH)D3 and IL8 and hsCRP levels were observed. Conclusions: Serum 25(OH)D3 levels were inversely associated with the summary inflammatory z-score and in particular with IL6 in the years following CRC diagnosis. This is of potential clinical relevance as IL6 has an important role in chronic inflammation and is also suggested to stimulate cancer progression. Further observational studies should investigate whether a possible 25(OH)D3-associated reduction of inflammatory mediators influences treatment efficacy and CRC recurrence.

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