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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 568465
Title Effect of peste des petits ruminants virus (PPRV) infection on the host immune response in naturally infected goats
Author(s) Das, S.; Choudhury, R.; Balamurugan, V.; Chakravarty, I.; Devi, M.; Bora, M.; Sharma, K.
Source The Indian Journal of Animal Sciences 87 (2017). - ISSN 0367-8318
Department(s) Host-Microbe Interactomics
Publication type Article in professional journal
Publication year 2017
Abstract Toll like receptors (TLRs) expressed by various immune cells and tissues are known to play an important role in recognising the pathogens by the host. The study was carried out to envisage the expression of virus-recognising-TLRs like TLR-3, TLR-7 and TLR-8 as well as the Th1 and Th2 cytokines in the serum of naturally Peste des petits ruminants virus (PPRV) infected goats. Goat serum samples, collected from three districts of Asom (Kamrup, Nalbari, Darrang), were screened for Peste des petits ruminants virus (PPRV) antibody by Complementary-ELISA. Out of 227 samples screened, 72 samples showed presence of PPR viral antibody with a percentage prevalence of 31.72%. Out of the positive samples, 39 were selected randomly for testing the TLR and cytokine response after PPRV infection. The study indicated TLR-8 to have an enhanced expression in serum of PPRV infected goats along
with IL-12 and IFN-γ of the Th1 pathway. Further, in infected group, a significant correlation was registered between IL-12 and IFN-γ. The present study showed the involvement of the Th-1 pathway in host immune response after PPRV natural infection which may help in proper disease management and control strategies.
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