Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 568525
Title Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)
Author(s) Molenaar, Robert Jan; Vreman, Sandra; Hakze-van der Honing, Renate W.; Zwart, Rob; Rond, Jan de; Weesendorp, Eefke; Smit, Lidwien A.M.; Koopmans, Marion; Bouwstra, Ruth; Stegeman, Arjan; Poel, Wim H.M. van der
Source Veterinary Pathology 57 (2020)5. - ISSN 0300-9858 - p. 653 - 657.
DOI https://doi.org/10.1177/0300985820943535
Department(s) Infection Biology
Virology
Diagnostics & Crisis Organization
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) COVID-19 - mink - pneumonia - respiratory disease - severe acute respiratory syndrome coronavirus 2 - zoonoses
Abstract

SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.

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