Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 568702
Title Acute porcine epidemic diarrhea virus infection reshapes the intestinal microbiota
Author(s) Yang, Shanshan; Li, Yang; Wang, Bin; Yang, Ning; Huang, Xin; Chen, Qingbo; Geng, Shuxian; Zhou, Yawei; Shi, Han; Wang, Leyi; Brugman, Sylvia; Savelkoul, Huub; Liu, Guangliang
Source Virology 548 (2020). - ISSN 0042-6822 - p. 200 - 212.
DOI https://doi.org/10.1016/j.virol.2020.07.001
Department(s) Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2020
Keyword(s) Intestinal microbiota - Pathogenicity - Porcine epidemic diarrhea virus
Abstract

The intestinal microbiota is crucial to intestinal homeostasis. Porcine epidemic diarrhea virus (PEDV) is high pathogenic to intestines, causing diarrhea, even death in piglets. To investigate the detailed relationship between PEDV infection and intestinal microbiota, the composition and distribution of intestinal microbiota from pigs were first analyzed using 16S rRNA sequencing technology. The results demonstrated that the composition and distribution of microbes in different intestinal segments were quite similar between 1-week-old and 2-week-old piglets but different from 4-week-old (weaned) piglets. Then piglets at different ages were inoculated with PEDV. The results showed that the 1-week-old piglets exhibited the most severe pathogenicity comparing to the other age groups. Further investigations indicated that Lactobacillus, Escherichia coli, and Lactococcus in the intestinal microbiota of piglets were significantly changed by PEDV infection. These results strengthen our understanding of viruses influencing intestinal microbes and remind us of the potential association between PEDV and intestinal microbes.

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