Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 64695
Title Serum carotenoids, alpha-tocopherol, and lung function among Dutch elderly
Author(s) Grievink, L.; Waart, F.G. de; Schouten, E.G.; Kok, F.J.
Source American Journal of Respiratory and Critical Care Medicine 161 (2000). - ISSN 1073-449X - p. 790 - 795.
Department(s) Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2000
Abstract Antioxidant vitamins (provitamins) may protect against loss of lung function over time. We studied the association between serum carotenoids (-carotene, -carotene, lycopene, -cryptoxanthin, zeaxanthin, and lutein), -tocopherol, and lung function among noninstitutionalized Dutch elderly age 65 to 85 yr (n = 528). Multiple linear regression analysis was performed with FEV1 or FVC as dependent variables and serum levels of antioxidants in quintiles as independent variables. We adjusted for age, gender, height, and pack-years of smoking. Subjects in the fifth quintile of serum -carotene had a 195 ml (95␌onfidence interval [95␌I]: 40 to 351 ml) higher and those in the fifth quintile of -carotene had a 257 ml (95␌I: 99 to 414 ml) higher FEV1 compared with subjects in the first quintile of these carotenoids. Significant (p < 0.05) positive trends were observed between -carotene, -carotene, lycopene, and FEV1 and between -carotene, -carotene, and FVC. Subjects in the highest quintile of the other carotenoids or -tocopherol did not have significantly higher FEV1 or FVC compared with subjects in the first quintile of these antioxidants. In conclusion, this study shows that from the six major serum carotenoids and -tocopherol studied, particularly -carotene, -carotene, and lycopene were positively associated with lung function in the elderly and may be considered as candidates for further investigations. Grievink L, de Waart FG, Schouten EG, Kok FJ. Serum carotenoids, -tocopherol, and lung function among Dutch elderly.
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