Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 66815
Title A molecular view of the intestinal ecosystem
Author(s) Vaughan, E.E.; Schut, F.; Heilig, G.H.J.; Zoetendal, E.G.; Vos, W.M. de; Akkermans, A.D.L.
Source Current Issues in Intestinal Microbiology 1 (2000). - ISSN 1466-531X - p. 1 - 12.
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2000
Abstract This review describes the state of the art as well as the initial results of molecular methodologies used to study the ecology of the complex microflora of the human intestinal tract. The detection and identification of many of these organisms has largely been hampered by the incomplete knowledge of their culture conditions. Many of the molecular methodologies are rooted in the use of ribosomal RNA (rRNA) and its encoding genes to describe the relationship between the bacteria in such communities and their individual identity. This approach permits the elucidation both qualitatively as well as quantitatively of the abundance of bacterial species and how their presence interacts with diet and health. Emphasis is given to the analysis of complex communities rather than detection of individual groups of bacteria. The potential of novel advances in molecular technologies such as DNA arrays for analysis of the intestinal ecosystem are also discussed.
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