Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 361547
Title Post alignment clustering procedure for comparative quantitative proteomics LC-MS Data
Author(s) Groot, J.C.W. de; Fiers, M.W.E.J.; Ham, R.C.H.J. van; America, A.H.P.
Source Proteomics 8 (2008)1. - ISSN 1615-9853 - p. 32 - 36.
DOI https://doi.org/10.1002/pmic.200700707
Department(s) PRI Bioscience
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) identification - proteins
Abstract Comparative LC-MS is a powerful method for detailed quantitative comparison of complex protein mixtures. Dedicated software is required for detection, matching, and alignment of peaks in multiple LC-MS datasets. However, retention time shifts, saturation effects, limitations of experimental accuracy, and possible occurrence of split peaks make it difficult for software to perfectly match all chromatograms. We describe a procedure to assess the above problems and show that dataset quality can be enhanced with the aid of cluster analysis.
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