|Title||Shooting the messenger : RNA-targetting CRISPR-Cas systems|
|Author(s)||Zhu, Yifan; Klompe, Sanne E.; Vlot, Marnix; Oost, John van der; Staals, Raymond H.J.|
|Source||Bioscience Reports 38 (2018)3. - ISSN 0144-8463|
|Publication type||Refereed Article in a scientific journal|
Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.