Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    The immune system: effects of water temperature and acidification.
    Muiswinkel, W.B. van - \ 2020
    In: Climate change and non-infectious fish disorders / Woo, P.T.K., Iwama, G.K., CABI - ISBN 9781786393982 - p. 218 - 236.
    This chapter provides a general overview of the defence mechanisms in fish, its interactions with the neuroendocrine system and the influence of environmental factors such as water temperature and acidification on its function.
    Vaccination against Spring Viraemia of Carp (SVC) - from the past till the future
    Muiswinkel, W.B. van; Pilarczyk, A. ; Rehulka, J. - \ 2018
    Bulletin of the European Association of Fish Pathologists 38 (2018)6. - ISSN 0108-0288
    In the period between 1970 and 1985 it was shown that injection of killed or attenuated virus was effective in preventing spring viraemia of carp (SVC) provided that the fish were vaccinated at optimal temperatures (≥ 18°C). Unfortunately, this approach was difficult to apply in traditional pond farming, where stocking often takes place in spring and autumn at temperatures far below 18°C. In recent years new and promising DNA vaccines (containing a glycoprotein of the SVC virus) have been developed, including a formulation that can be injected or given by oral route (feeding). These developments open new possibilities for protection of young fish and/or vaccination at optimal temperatures giving durable protection in traditional pond farming of carp.
    Polish scientists in fish immunology: a short history : review
    Muiswinkel, W.B. van; Pilarczyk, A. - \ 2015
    Biology - open access biological sciences journal 4 (2015)4. - ISSN 2079-7737 - p. 735 - 755.
    This review describes the role played by Polish scientists in the field of fish immunology and vaccination starting around 1900. In the early days, most publications were dealing with a description of relevant cells and organs in fish. Functional studies (phagocytosis, antibody response) came later starting in the late 1930s. Detailed papers on fish vaccination were published from 1970 onwards. Another important development was the unraveling of neuro-endocrine-immune interactions in the 1970s until today. Around 1980, it became more and more clear how important immunomodulation (stimulation or suppression by environmental factors, food components, drugs) was for fish health. The most recent findings are focusing on the discovery of genetic factors, signaling molecules, and receptors, which play a crucial role in the immune response. It can be concluded, that Polish scientists made considerable contributions to our present understanding of fish immunity and to applications in aquaculture worldwide.
    A short history of research on immunity to infectious diseases in fish
    Muiswinkel, W.B. van; Nakao, M. - \ 2014
    Developmental and Comparative Immunology 43 (2014)2. - ISSN 0145-305X - p. 130 - 150.
    carp cyprinus-carpio - trout oncorhynchus-mykiss - salmon salmo-salar - 2nd gut segment - atypical aeromonas-salmonicida - viral hemorrhagic septicemia - hematopoietic necrosis virus - c-reactive protein - ig heavy-chain - mhc class-ii
    This review describes the history of research on immunity to infectious diseases of fish in the period between 1965 and today. Special attention is paid to those studies, which are dealing with the interaction between immune system and invading pathogens in bony fish. Moreover, additional biographic information will be provided of people involved. In the 1960s and 1970s the focus of most studies was on humoral (Ig, B-cell) responses. Thorough studies on specific cellular (T-cell) responses and innate immunity (lectins, lysozyme, interferon, phagocytic cells) became available later. In the period between 1980 and today an overwhelming amount of data on regulation (e.g. cell cooperation, cytokines) and cell surface receptors (e.g. T-cell receptor; MHC) was published. It became also clear, that innate responses were often interacting with the acquired immune responses. Fish turned out to be vertebrates like all others with a sophisticated immune system showing specificity and memory. These basic data on the immune system could be applied in vaccination or in selection of disease resistant fish. Successful vaccines against bacterial diseases became available in the 1970s and 1980s. Effective anti-viral vaccines appeared from the 1980s onwards. There is no doubt, that Fish Immunology has become a flourishing science by the end of the 20th century and has contributed to our understanding of fish diseases as well as the success of aquaculture.
    A history of fish vaccination. Science-based disease prevention in aquaculture
    Gudding, R. ; Muiswinkel, W.B. van - \ 2013
    Fish and Shellfish Immunology 35 (2013)6. - ISSN 1050-4648 - p. 1683 - 1688.
    rainbow-trout - vibrio-anguillarum - maternal immunity - oral immunization - yersinia-ruckeri - direct immersion - salmo-gairdneri - vaccines - salmonicida - fry
    Disease prevention and control are crucial in order to maintain a sustainable aquaculture, both economically and environmentally. Prophylactic measures based on stimulation of the immune system of the fish have been an effective measure for achieving this goal. Immunoprophylaxis has become an important part in the successful development of the fish-farming industry. The first vaccine for aquaculture, a vaccine for prevention of yersiniosis in salmonid fish, was licensed in USA in 1976. Since then the use of vaccines has expanded to new countries and new species simultaneous with the growth of the aquaculture industry. This paper gives an overview of the achievements in fish vaccinology with particular emphasis on immunoprophylaxis as a practical tool for a successful development of bioproduction of aquatic animals.
    Personal memories
    Muiswinkel, W.B. van - \ 2012
    NNA Berichte/Reports 24 (2012)1. - ISSN 0935-1450 - p. 28 - 29.
    A short history of fish immunology and vaccination
    Muiswinkel, W.B. van - \ 2011
    In: Proceedings of the International conference "Problems of immunology, pathology and health protection of fish and other hydrobionts", Borok, Russia. - - p. 80 - 80.
    Antibiotica, een vloek of een zegen?
    Muiswinkel, W.B. van - \ 2011
    Aquacultuur 6 (2011)2. - ISSN 1382-2764 - p. 38 - 39.
    antibiotica - oxytetracycline - aquacultuur - visteelt - immuunsysteem - antibiotics - oxytetracycline - aquaculture - fish culture - immune system
    In Aquacultuur 2010, nr. 5 stond op pagina 33 van het artikel "Aan tafel bij Sietze Leenstra" de opmerking, dat antibiotica het immuunsysteem verstoren. Hier is wel iets voor te zeggen, maar toch moeten we oppassen, dat we niet alle antibiotica op één hoop smijten. Volgens de auteur is het vooral het gebruik van oxytetracycline in de aquacultuur, waar we een vraagteken bij moeten plaatsen.
    A short history of fish immunology and vaccination
    Muiswinkel, W.B. van - \ 2010
    In: Abstracts of the 35th Annual Eastern Fish Health Workshop, Shepherdstown, West Virginia, USA, 24-28 May 2010. - - p. 18 - 18.
    History of Fish Immunology and Vaccination II. The Flourishing years (1950-2000)
    Muiswinkel, W.B. van - \ 2009
    In: Book of Abstracts 11th Congress of the International Society of Developmental and Comparative Immunology. Prague, Czech Republic, 28 June - 04 July, 2009. - - p. 194 - 194.
    History of Fish Immunology and Vaccination I. The early years (1850-1950)
    Muiswinkel, W.B. van - \ 2009
    In: Book of Abstracts 11th Congress of the International Society of Developmental and Comparative Immunology. Prague, Czech Republic, 28 June - 04 July, 2009. - - p. 194 - 194.
    History of Fish Immunology and Vaccination
    Muiswinkel, W.B. van - \ 2008
    A history of fish immunology and vaccination I. the early days
    Muiswinkel, W.B. van - \ 2008
    Fish and Shellfish Immunology 25 (2008)4. - ISSN 1050-4648 - p. 397 - 408.
    trout salmo-gairdneri - dogfish mustelus canis - immune-response - immunoglobulin structure - oral immunization - antibody - carp - evolution - shark - homotransplantation
    This historic review describes the people that were involved in studying some aspect of fish immunology and vaccination from as early as 1854. Between 1850 and 1940, most scientists were looking at fish from the angle of comparative anatomy, embryology, physiology, taxonomy and fish diseases. Most publications from this early period are describing the morphology of blood cells and hemopoietic or lymphoid organs. The first publications on specific immune responses and vaccination of fish were found in the period 1935-1938. However, the immune mechanisms behind protective immunization were largely unknown in those days. In the period after 1940, the first researchers can be found devoting their whole career to fish immunology. This paper has been organized largely by individuals and not so much by accomplishments. It is not the intent of this review to evaluate the scientific merit of the work discussed, but to provide the reader with information that was - at least in part - lost to the scientific community. Publications from before 1940 or in languages other than English (e.g. Russian) are usually not found by today's database searches on the Internet.
    The early days of fish immunology. A short history
    Muiswinkel, W.B. van - \ 2007
    In: Proceedings of the 7th Nordic Symposium on Fish Immunology, Stirling, Scotland, 19- 22 June, 2007. - - p. 42 - 42.
    The immune system of fish
    Muiswinkel, W.B. van; Vervoorn-Van der Wal, B. - \ 2006
    In: Fish Diseases and Disorders / Woo, P.T.K., CAB International - ISBN 9780851990156 - p. 678 - 701.
    This chapter provides a general overview of the defence mechanisms in fish.
    Most data are derived from bony fish, but some interesting differences with cartilaginous or jawless fish will be discussed. It is known from fossil remains that the earliest fish appeared some 350–400 million years ago. This implies that unique specializations in the defence systems of certain fish species may have developed over the years
    Final evaluation report NWO-LNV priority programme "limits to animal welfare and production" : (Chapter 3) Research on fish health problems in aquaculture
    Muiswinkel, W.B. van - \ 2006
    The Hague : NWO - 9 p.
    The ontogeny of mucosal immune cells in common carp (Cyprinus carpio L.)
    Huttenhuis, B.T. ; Romano, N. ; Oosterhoud, C.N. van; Taverne-Thiele, J.J. ; Mastrolia, L. ; Muiswinkel, W.B. van; Rombout, J.H.W.M. - \ 2006
    Anatomy and Embryology 211 (2006)1. - ISSN 0340-2061 - p. 19 - 29.
    vibrio-anguillarum bacterin - 2nd gut segment - intraepithelial lymphocytes - v(d)j recombination - t-cells - immunological importance - lymphoid-tissue - teleost fish - b-cells - expression
    The ontogeny of carp (Cyprinus carpio L.) immune cells was studied in mucosal organs (intestine, gills and skin) using the monoclonal antibodies WCL38 (intraepithelial lymphocytes), WCL15 (monocytes/macrophages) and WCI12 (B cells). In addition, recombination activating gene 1 expression was examined in the intestine with real time quantitative PCR and in situ hybridization to investigate extrathymic generation of lymphocytes. WCL38+ intraepithelial lymphocytes (putative T cells) appeared in the intestine at 3 days post-fertilization (dpf), which is shortly after hatching but before feeding, implying an important function at early age. These lymphoid cells appear in the intestine before the observation of the first thymocytes at 3¿4 dpf, and together with the expression of recombination activating gene 1 in the intestine, suggests that similar to mammals at least part of these cells are generated in the intestine. WCL15+ monocytes/macrophages appeared in the lamina propria of the intestine at 7 dpf, but considerably later in the epithelium, while WCI12+ (B) cells appeared in intestine and gills at 6¿7 weeks. From these results it can be concluded that putative T cells occur much earlier than B cells, and that B cells appear much later in the mucosae than in other internal lymphoid organs (2 wpf).
    Onbekend maakt onbemind, geschiedenis van de immunologie
    Muiswinkel, W.B. van - \ 2004
    NVOX Tijdschrift voor Natuurwetenschap op School 8 (2004). - ISSN 0929-757X - p. 406 - 407.
    Appearance, activation and function on the carp innate immune system from hatching onwards
    Huttenhuis, B.T. ; Saeij, J.P.J. ; Muiswinkel, W.B. van; Rombout, J.H.W.M. - \ 2003
    In: 9th International Congress of ISDCI, St Andrews Scotland; Programme & Abstracts. - - p. 86 - 86.
    Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool
    Saeij, J.P.J. ; Muiswinkel, W.B. van; Meent, M. van de; Amaral, C. ; Wiegertjes, G.F. - \ 2003
    Developmental and Comparative Immunology 27 (2003). - ISSN 0145-305X - p. 555 - 568.
    ornithine decarboxylase - cellular glutathione - gene-expression - cyprinus-carpio - flow-cytometry - cells - no - biosynthesis - cytotoxicity - variability
    Carp head kidney (HK) phagocytes can be stimulated by lipopolysaccharide (LPS) to produce nitric oxide (NO). High production of NO can suppress the carp immune system. Carp peripheral blood leukocytes (PBL) are highly susceptible but HK phagocytes are relatively resistant to the immunosuppressive effects of NO. This study demonstrates that the antioxidant glutathione plays an important role in the protection against nitrosative stress. Carp HK phagocytes, especially the neutrophilic granulocytes, contain higher levels of glutathione than PBL. Moreover, freshly isolated carp neutrophilic granulocytes have higher mRNA levels than PBL of glucose-6-phosphate dehydrogenase (G6PD), manganese superoxide dismutase (MnSOD) and gamma-glutamylcysteine synthetase (gamma-GCS). Since these molecules are part of the glutathione redox cycle, neutrophilic granulocytes have a higher capacity than PBL to maintain glutathione in a reduced state following nitrosative stress. When stimulated with LPS, neutrophilic granulocytes upregulate the expression of G6PD, MnSOD and gamma-GCS. (C) 2002 Published by Elsevier Science Ltd.
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