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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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    The Maastricht-FFQ: Development and Validation of a Comprehensive Food Frequency Questionnaire for The Maastricht Study
    Dongen, Martien C.J.M. van; Wijckmans-Duysens, Nicole E.G. ; Biggelaar, Louise J.C.J. den; Ock, Marga C. ; Meijboom, S. ; Brants, H.A.M. ; Vries, J.H.M. de; Feskens, E.J.M. ; Bueno-de-Mesquita, H.B. ; Geelen, M.M.E.E. ; Stehouwer, C.D.A. ; Dagnelie, Pieter C. ; Eussen, Simone J.P.M. - \ 2019
    Nutrition 62 (2019). - ISSN 0899-9007
    Objective: To develop and validate a comprehensive food frequency questionnaire (FFQ) for The Maastricht Study, a population-based prospective cohort study in Maastricht, The Netherlands. Research Methods & Procedures: Item selection for the FFQ was based on explained variation and contribution to intake of energy and 24 nutrients. For validation, the FFQ was filled out by 135 participants (25-70 years) of the Nutrition Questionnaires plus study. Per person, on average 2.8 (range 1 to 5) telephone-based 24h dietary recalls (24hRs), two 24h urinary samples and one blood sample were available. Validity of 54 nutrients and 22 food groups was assessed by ranking agreement, correlation coefficients, attenuation factors, and ultimately de-attenuated correlation coefficients (validity coefficients). Results: Median correlation coefficients for energy and macronutrients, micronutrients and food groups were 0.45, 0.36 and 0.38, respectively. Median de-attenuated correlation coefficients were 0.53 for energy and macronutrients, 0.45 for micronutrients and 0.64 for food groups, being >0.50 for 18 out of 22 macronutrients and 16 out of 30 micronutrients, and >0.50 for 17 out of 22 food groups. The FFQ underestimated protein and potassium intake compared to 24h urinary nitrogen and potassium excretion by -18% and -2%, respectively. Correlation coefficients ranged from 0.50 and 0.55 for (fatty) fish intake and plasma EPA and DHA, and from 0.26-0.42 between fruit and vegetable intake and plasma carotenoids. Conclusion: Overall, the validity of the 253-item Maastricht-FFQ is good. The comprehensiveness of this FFQ make it well-suited for use in The Maastricht Study and similar populations.
    Voeding Slim Thuis: Voedingsadvies op maat ondersteund met warme maaltijden
    Doets, Esmee ; Meijboom, S. ; Haar, S. van der; Paling, Odette ; Timmer, M.J. - \ 2019
    A national FFQ for the Netherlands (the FFQ-NL1.0): development and compatibility with existing Dutch FFQs
    Eussen, Simone ; Dongen, M.C.J.M. van; Wijckmans, N.E. ; Meijboom, S. ; Brants, H.A.M. ; Vries, J.H.M. de; Bueno-de-Mesquita, H.B. ; Geelen, M.M.E.E. ; Sluik, D. ; Feskens, E.J.M. ; Ocke, M.C. ; Dagnelie, P.C. - \ 2018
    Public Health Nutrition 21 (2018)12. - ISSN 1368-9800 - p. 2221 - 2229.
    Objective In the Netherlands, various FFQs have been administered in large cohort studies, which hampers comparison and pooling of dietary data. The present study aimed to describe the development of a standardized Dutch FFQ, FFQ-NL1.0, and assess its compatibility with existing Dutch FFQs. Design Dutch FFQTOOLTM was used to develop the FFQ-NL1.0 by selecting food items with the largest contributions to total intake and explained variance in intake of energy and thirty-nine nutrients in adults aged 25–69 years from the Dutch National Food Consumption Survey (DNFCS) 2007–2010. Compatibility with the Maastricht-FFQ, Wageningen-FFQ and EPICNL-FFQ was assessed by comparing the number of food items, the covered energy and nutrient intake, and the covered variance in intake. Results FFQ-NL1.0 comprised 160 food items, v. 253, 183 and 154 food items for the Maastricht-FFQ, Wageningen-FFQ and EPICNL-FFQ, respectively. FFQ-NL1.0 covered ≥85 % of energy and all nutrients reported in the DNFCS. Covered variance in intake ranged from 57 to 99 % for energy and macronutrients, and from 45 to 93 % for micronutrients. Differences between FFQ-NL1.0 and the other FFQs in covered nutrient intake and covered variance in intake were <5 % for energy and all macronutrients. For micronutrients, differences between FFQ-NL and other FFQs in covered level of intake were <15 %, but differences in covered variance were much larger, the maximum difference being 36 %. Conclusions The FFQ-NL1.0 was compatible with other FFQs regarding energy and macronutrient intake. However, compatibility for covered variance of intake was limited for some of the micronutrients. If implemented in existing cohorts, it is advised to administer the old and the new FFQ in combination to derive calibration factors.
    Evaluation of dietary intake assessed by the Dutch self-administered web-based dietary 24-h recall tool (Compl-eat™) against interviewer-administered telephone-based 24-h recalls
    Meijboom, Saskia ; Houts-Streppel, Martinette T. van; Perenboom, Corine ; Siebelink, Els ; Wiel, Anne M. van de; Geelen, Anouk ; Feskens, Edith J.M. ; Vries, Jeanne H.M. de - \ 2017
    Journal of Nutritional Science 6 (2017). - ISSN 2048-6790 - 10 p.
    24-h Dietary recalls - Comparative studies - Dietary assessment - Internet

    Self-administered web-based 24-h dietary recalls (24 hR) may save a lot of time and money as compared with interviewer-administered telephone-based 24 hR interviews and may therefore be useful in large-scale studies. Within the Nutrition Questionnaires plus (NQplus) study, the web-based 24 hR tool Compl-eat™ was developed to assess Dutch participants’ dietary intake. The aim of the present study was to evaluate the performance of this tool against the interviewer-administered telephone-based 24 hR method. A subgroup of participants of the NQplus study (20–70 years, n 514) completed three self-administered web-based 24 hR and three telephone 24 hR interviews administered by a dietitian over a 1-year period. Compl-eat™ as well as the dietitians guided the participants to report all foods consumed the previous day. Compl-eat™ on average underestimated the intake of energy by 8 %, of macronutrients by 10 % and of micronutrients by 13 % as compared with telephone recalls. The agreement between both methods, estimated using Lin's concordance coefficients (LCC), ranged from 0·15 for vitamin B1 to 0·70 for alcohol intake (mean LCC 0·38). The lower estimations by Compl-eat™ can be explained by a lower number of total reported foods and lower estimated intakes of the food groups, fats, oils and savoury sauces, sugar and confectionery, dairy and cheese. The performance of the tool may be improved by, for example, adding an option to automatically select frequently used foods and including more recall cues. We conclude that Compl-eat™ may be a useful tool in large-scale Dutch studies after suggested improvements have been implemented and evaluated.

    Habitual diet and diet quality in Irritable Bowel Syndrome: A case-control study
    Tigchelaar, Ettje F. ; Mujagic, Zlatan ; Zhernakova, Alexandra ; Hesselink, M. ; Meijboom, S. ; Perenboom, C.W.M. ; Masclee, A.A.M. ; Wijmenga, Cisca ; Feskens, E.J.M. ; Jonkers, D. - \ 2017
    Neurogastroenterology & Motility 29 (2017)12. - ISSN 1365-2982
    Background Diet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality. Methods We evaluated habitual dietary intake in IBS patients with regard to nutrients and food products using an extensive food frequency questionnaire. One hundred ninety-four IBS patients were compared to 186 healthy controls using multiple logistic regression analysis. An overall diet quality score was calculated for each participant based on the criteria of the Dutch Healthy Diet (DHD) index. Key Results A lower DHD-score was found for IBS (mean [SD]: 52.9 [9.6]) vs controls (55.1 [9.2], P=.02). The diet of patients was lower in fibers (21 g vs 25 g per day, P=.002) and fructose (14 g vs 16 g, P=.033), while higher in total fat (37% vs 36% of total energy intake, P=.010) and added sugars (46 g vs 44 g, P=.029). Differences in daily intake of food products included lower consumption of apples (40 g vs 69 g, P<.001), pasta (28 vs 37 g, P=.029) and alcoholic beverages (130 g vs 193 g, P=.024) and higher consumption of processed meat (38 g vs 29 g, P<.001). Some of these findings correlated with gastrointestinal symptoms, showing differences between IBS subtypes. Conclusions and Inferences Differences in habitual diet were described, showing lower diet quality in IBS patients compared to controls, with increased consumption of fat and lower intake of fibers and fructose. Our data support the importance of personalized and professional nutritional guidance of IBS patients.
    Development and evaluation of the Dutch Healthy Diet index 2015
    Looman, M. ; Feskens, E.J.M. ; Rijk, M.G. de; Meijboom, S. ; Briesbroek, S. ; Temme, E.H.M. ; Vries, J.H.M. de; Geelen, M.M.E.E. - \ 2017
    Public Health Nutrition 20 (2017)13. - ISSN 1368-9800 - p. 2289 - 2299.
    To update the Dutch Healthy Diet index, a measure of diet quality, to reflect adherence to the Dutch dietary guidelines 2015 and to evaluate against participants’ characteristics and nutrient intakes with the score based on 24 h recall (24 hR) data and FFQ data.
    The Dutch Healthy Diet index 2015 (DHD15-index) consists of fifteen components representing the fifteen food-based Dutch dietary guidelines of 2015. Per component the score ranges between 0 and 10, resulting in a total score between 0 (no adherence) and 150 (complete adherence).
    Wageningen area, the Netherlands, 2011–2013.
    Data of 885 men and women, aged 20–70 years, participating in the longitudinal NQplus study, who filled out two 24 hR and one FFQ, were used.
    Mean (sd) score of the DHD15-index was 68·7 (16·1) for men and 79·4 (16·0) for women. Significant inverse trends were found between the DHD15-index and BMI, smoking, and intakes of energy, total fat and saturated fat. Positive trends were seen across sex-specific quintiles of the DHD15-index score with energy-adjusted micronutrient intakes. Mean DHD15-index score of the FFQ data was 15·5 points higher compared with 24 hR data, with a correlation coefficient of 0·56 between the scores. Observed trends of the DHD15-index based on FFQ with participant characteristics, macronutrient and energy-adjusted micronutrient intakes were similar to those with the DHD15-index based on 24 hR.
    The DHD15-index score assesses adherence to the Dutch dietary guidelines 2015 and indicates diet quality. The DHD15-index score can be based on 24 hR data and on FFQ data.
    A national FFQ for the Netherlands (the FFQ-NL 1.0): validation of a comprehensive FFQ for adults
    Sluik, D. ; Geelen, M.M.E.E. ; Vries, J.H.M. de; Eussen, S.J.P.M. ; Brants, H.A.M. ; Meijboom, S. ; Dongen, Martien C.J.M. van; Bueno-de Mesquita, H.B. ; Veer, P. van 't; Feskens, E.J.M. - \ 2016
    The British journal of nutrition 116 (2016)5. - ISSN 0007-1145 - p. 913 - 923.
    A standardised, national, 160-item FFQ, the FFQ-NL 1.0, was recently developed for Dutch epidemiological studies. The objective was tovalidate the FFQ-NL 1.0 against multiple 24-h recalls (24hR) and recovery and concentration biomarkers. The FFQ-NL 1.0 was filled out by383 participants (25–69 years) from the Nutrition Questionnaires plus study. For each participant, one to two urinary and blood samples andone to five (mean 2·7) telephone-based 24hR were available. Group-level bias, correlation coefficients, attenuation factors, de-attenuatedcorrelation coefficients and ranking agreement were assessed. Compared with the 24hR, the FFQ-NL 1.0 estimated the intake of energy andmacronutrients well. However, it underestimated intakes of SFA and trans-fatty acids and alcohol and overestimated intakes of most vitaminsby >5%. The median correlation coefficient was 0·39 for energy and macronutrients, 0·30 for micronutrients and 0·30 for food groups. TheFFQ underestimated protein intake by an average of 16% and K by 5 %, relative to their urinary recovery biomarkers. Attenuation factors were0·44 and 0·46 for protein and K, respectively. Correlation coefficients were 0·43–0·47 between (fatty) fish intake and plasma EPA and DHA and0·24–0·43 between fruit and vegetable intakes and plasma carotenoids. In conclusion, the overall validity of the newly developed FFQ-NL 1.0was acceptable to good. The FFQ-NL 1.0 is well suited for future use within Dutch cohort studies among adults.
    Response to the 'Letter to the Editor on the Maastricht Sarcopenia Study'
    Borg, Sovianne ter; Verlaan, Sjors ; Groot, Lisette C.P.G.M. de; Vries, Jeanne H.M. de; Meijboom, Saskia ; Mijnarends, Donja M. ; Luiking, Yvette C. ; Schols, Jos M.G.A. - \ 2016
    Journal of the American Medical Directors Association 17 (2016)1. - ISSN 1525-8610 - p. 557 - 558.
    Evaluation of a screener to assess diet quality in the Netherlands
    Lee, L. van; Feskens, E.J.M. ; Meijboom, S. ; Hooft Van Huysduynen, E.J.C. ; Veer, P. van 't; Vries, J.H.M. de; Geelen, A. - \ 2016
    The British journal of nutrition 115 (2016)3. - ISSN 0007-1145 - p. 517 - 526.
    Generally, there is a need for short questionnaires to estimate diet quality in the Netherlands. We developed a thirty-four-item FFQ - the Dutch Healthy Diet FFQ (DHD-FFQ) - to estimate adherence to the most recent Dutch guidelines for a healthy diet of 2006 using the DHD-index. The objectives of the present study were to evaluate the DHD-index derived from the DHD-FFQ by comparing it with the index based on a reference method and to examine associations with participant characteristics, nutrient intakes and levels of cardiometabolic risk factors. Data of 1235 Dutch men and women, aged between 20 and 70 years, participating in the Nutrition Questionnaires plus study were used. The DHD-index was calculated from the DHD-FFQ and from a reference method consisting of a 180-item FFQ combined with a 24-h urinary Na excretion value. Ranking was studied using Spearman's correlations, and absolute agreement was studied using a Bland-Altman plot. Nutrient intakes derived from the 180-item FFQ were studied according to quintiles of the DHD-index using DHD-FFQ data. The correlation between the DHD-index derived from the DHD-FFQ and the reference method was 0·56 (95 % CI 0·52, 0·60). The Bland-Altman plot showed a small mean overestimation of the DHD-index derived from the DHD-FFQ compared with the reference method. The DHD-index score was in the favourable direction associated with most macronutrient and micronutrient intakes when adjusted for energy intake. No associations between the DHD-index score and cardiometabolic risk factors were observed. In conclusion, the DHD-index derived from the DHD-FFQ was considered acceptable in ranking but relatively poor in individual assessment of diet quality.
    Differences in nutriënt intake and biochemical nutriënt status between sarcopenic and nonsarcopenic older adults - results from the Maastricht Sarcopenia Study
    Borg, S. ter; Groot, C.P.G.M. de; Mijnarends, D. ; Vries, J.H.M. de; Verlaan, S. ; Meijboom, S. ; Luiking, Y.C. ; Schols, J.M.G.A. - \ 2016
    Journal of the American Medical Directors Association 17 (2016)5. - ISSN 1525-8610 - p. 393 - 401.
    Background There is growing evidence of a relationship between nutrients and muscle mass, strength, and physical performance. Although nutrition is seen as an important pillar of treating sarcopenia, data on the nutritional intake of sarcopenic older adults are limited. Objective To investigate potential nutritional gaps in the sarcopenic population, the present study compared nutrient intake and biochemical nutrient status between sarcopenic and nonsarcopenic older adults. Design The Maastricht Sarcopenia Study included 227 community-dwelling older adults (≥65 years) from Maastricht, 53 of whom were sarcopenic based on the European Working Group on Sarcopenia in Older People algorithm. Habitual dietary intake was assessed with a food frequency questionnaire and data on dietary supplement use were collected. In addition, serum 25-hydroxyvitamin D, magnesium and α-tocopherol/cholesterol, plasma homocysteine and red blood cell n-3, and n-6 fatty acids profiles were assessed. Nutrient intake and biochemical nutrient status of the sarcopenic groups were compared with those of the nonsarcopenic groups. The robustness of these results was tested with a multiple regression analysis, taking into account between-group differences in characteristics. Results Sarcopenic older adults had a 10%–18% lower intake of 5 nutrients (n-3 fatty acids, vitamin B6, folic acid, vitamin E, magnesium) compared with nonsarcopenic older adults (P < .05). When taking into account dietary supplement intake, a 19% difference remained for n-3 fatty acids intake (P = .005). For the 2 biochemical status markers, linoleic acid and homocysteine, a 7% and 27% difference was observed, respectively (P < .05). The higher homocysteine level confirmed the observed lower vitamin B intake in the sarcopenic group. Observed differences in eicosapentaenoic acid and 25-hydroxyvitamin D between the groups were related to differences in age and living situation. Conclusions Sarcopenic older adults differed in certain nutritional intakes and biochemical nutrient status compared with nonsarcopenic older adults. Dietary supplement intake reduced the gap for some of these nutrients. Targeted nutritional intervention may therefore improve the nutritional intake and biochemical status of sarcopenic older adults.
    Development of the HELIUS food frequency questionnaires ethnic-specific questionnaires to assess the diet of a multiethnic population in The Netherlands
    Beukers, M.H. ; Dekker, L.H. ; Boer, E.J. de; Perenboom, C.W.M. ; Meijboom, S. ; Nicolaou, M. ; Vries, J.H.M. de; Brants, H.A.M. - \ 2015
    European Journal of Clinical Nutrition 69 (2015). - ISSN 0954-3007 - p. 579 - 584.
    risk-factors - cardiovascular-disease - health - prevalence - europe - immigrants - chinese - cohort
    Objectives: Ethnic minorities are often not included in studies of diet and health because of a lack of validated instruments to assess their habitual diets. Given the increased ethnic diversity in many high-income countries, insight into the diets of ethnic minorities is needed for the development of nutritional policies and interventions. In this paper, we describe the development of ethnic-specific food frequency questionnaires (FFQs) to study the diets of Surinamese (African and South Asian), Turkish, Moroccan and ethnic Dutch residents of The Netherlands. Methods: An existing Dutch FFQ was adapted and formed the basis for three new FFQs. Information on food intake was obtained from single 24¿h recalls. Food items were selected according to their percentage contribution to and variance in absolute nutrient intake of the respective ethnic groups. A nutrient database for each FFQ was constructed, consisting of data from the Dutch Food Composition table; data on ethnic foods were based on new chemical analyses and available international data. Results: We developed four ethnic-specific FFQs using a standardised approach that included ~200 food items each and that covered more than 90% of the intake of the main nutrients of interest. Conclusions: The developed FFQs will enable standardised and comparable assessment of the diet of five different ethnic groups and provide insight into the role of diet in differences in health between ethnic groups. The methodology described in this paper and the choices made during the development phase may be useful in developing similar FFQs in other settings.
    Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study
    Streppel, M.T. ; Vries, J.H.M. de; Meyboom, S. ; Beekman, M. ; Craen, A.J.M. ; Slagboom, P.E. ; Feskens, E.J.M. - \ 2013
    Nutrition Journal 12 (2013). - ISSN 1475-2891 - 8 p.
    basal metabolic-rate - energy-intake - goldberg cutoff - limitations - validation - markers - design
    Background - Invalid information on dietary intake may lead to false diet-disease associations. This study was conducted to examine the relative validity of the food frequency questionnaire (FFQ) used to assess dietary intake in the Leiden Longevity Study. Methods - A total of 128 men and women participating in the Leiden Longevity Study were included in the present validation study. The performance of the FFQ was evaluated using the mean of three 24-hour recalls as the reference method. Evaluation in estimating dietary intake at the group level was done by paired t-tests. The relative validity of the individual energy adjusted level of intake was assessed with correlation analyses (Pearson’s), with correction for measurement error. Results - On group level, the FFQ overestimated as well as underestimated absolute intake of various nutrients and foods. The Bland and Altman plot for total energy intake showed that the agreement between the FFQ and the 24-hour recalls was dependent of intake level. Pearson correlation coefficients ranged from 0.21 (alpha linolenic acid) to 0.78 (ethanol) for nutrients and from -0.02 (legumes, non-significant) to 0.78 (alcoholic beverages) for foods. Adjustment for energy intake slightly lowered the correlation coefficients for nutrients (mean coefficient: 0.48 versus 0.50), while adjustment for within-subject variation in the 24-h recalls resulted in higher correlation coefficients for both nutrients and foods (mean coefficient: 0.69 for nutrients and 0.65 for foods). Conclusions - For most nutrients and foods, the ability of the FFQ to rank subjects was acceptable to good.
    Fat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice
    Laar, F.A. van de; Lisdonk, E.H. van de; Lucassen, P.L.B.J. ; Tigchelaar, J.M.H. ; Meyboom, S. - \ 2004
    British Journal of General Practice 54 (2004)500. - ISSN 0960-1643 - p. 177 - 182.
    mellitus - risk - diet
    Although treatment targets for the consumption of dietary fat in patients with type 2 diabetes mellitus are well accepted, little is known about the actual fat consumption by newly diagnosed patients or the dietary adjustments that they make in the following years. AIMS: To measure fat intake in patients with type 2 diabetes in general practice at diagnosis, shortly after dietary consultation, and after 4 years. DESIGN OF STUDY: A prospective cohort study. SETTING: Thirty-three general practices in The Netherlands. METHOD: One hundred and forty-four patients with newly diagnosed type 2 diabetes were referred to a dietician, and fat consumption (the main outcome measure) was assessed with a 104-item food frequency questionnaire at diagnosis, 8 weeks following diagnosis, and after 4 years. Reference values for fat consumption were obtained from an age-matched sample of a population-based survey. RESULTS: At diagnosis, total energy intake was 10.6 MJ/day and cholesterol intake was 300 mg/day. Total fat consumption was 40.9% of energy intake, with saturated fatty acids 15.0%, monounsaturated fatty acids 14.3%, and polyunsaturated fatty acids 9.2% of energy intake. All levels, except for polyunsaturated fatty acids, were significantly unfavourable compared with those for the general population. After 8 weeks, consumption of saturated fatty acids had decreased to a lower level than in the general population and all other levels measured were similar to those for the general population. After 4 years there was a slight increase in the consumption of total fat and monounsaturated fatty acids, but cholesterol and saturated fatty acid consumption had decreased further. CONCLUSIONS: Patients with newly diagnosed type 2 diabetes have an unfavourable fat consumption at diagnosis. They adapt to a more desirable consumption shortly after diagnosis, and this improved dietary behaviour is sustained for 4 years. Recommendations regarding consumption of total and saturated fat are, in contrast to those for cholesterol, not met by patients in general practice.
    Influence of processing on total, monoglutamate and polyglutamate folate contents of leeks, cauliflower, and green beans
    Melse-Boonstra, A. ; Verhoef, P. ; Konings, E.J. ; Dusseldorp, M. van; Matser, A. ; Hollman, P.C.H. ; Meyboom, S. ; Kok, F.J. ; West, C.E. - \ 2002
    Journal of Agricultural and Food Chemistry 50 (2002)12. - ISSN 0021-8561 - p. 3473 - 3478.
    Bioavailability of dietary folate might be impaired by the polyglutamate chain to which ~70␘f dietary folates are bound. This chain must be removed enzymatically in the intestine before folate is absorbed as a monoglutamate. To increase formation of monoglutamate folate in vegetables, the vegetables were subjected to various processing treatments. Treatments included freezing (-18 C, 16 h) and thawing (4 C, 24 h) and hydrostatic high-pressure treatment (200 MPa, 5 min). Both freezing/thawing and high-pressure treatment increased the proportion of folate in the monoglutamate form in leeks, cauliflower, and green beans 2-3-fold. However, loss of total folate after these treatments was >55ÐIt is concluded that conversion of folate polyglutamate to the monoglutamate form in vegetables is possible by certain processing treatments. Potentially this could lead to vegetables with higher folate bioavailability. However, to prevent folate loss into processing water, processing in a closed system should be applied.
    Can folate bioavailability from vegetables be increased by processing treatments that stimulates endogenous glutamate carboxypeptidase II activity?
    Melse-Boonstra, A. ; Verhoef, P. ; Konings, E.J.M. ; Dusseldorp, M. van; Matser, A. ; Hollman, P.C.H. ; Meyboom, S. ; West, C.E. - \ 2001
    In: Bioavailability 2001, Interlaken Congres Centre, Switzerland, may 29-june 1, 2001
    The apoproteinA4-1/2 polymorphism does not affect the response of serum lipids to dietary cholesterol in humans
    Weggemans, R.M. ; Zock, P.L. ; Meyboom, S. ; Funke, H. ; Katan, M.B. - \ 2001
    In: Cardiovascular Genomics : First Netherlands Heart Foundation National Scientific Meeting, 18 april 2001, Utrecht, the Netherlands. - [S.l.] : [s.n.], 2001 - p. 55 - 55.
    Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers
    Vissers, M.N. ; Zock, P.L. ; Wiseman, S.A. ; Meyboom, S. ; Katan, M.B. - \ 2001
    European Journal of Clinical Nutrition 55 (2001). - ISSN 0954-3007 - p. 334 - 341.
    Objective: We studied whether consumption of phenol-rich extra virgin olive oil affects the susceptibility of low density lipoproteins (LDL) to oxidation and other markers of oxidation in humans. Design: Randomized cross-over intervention trial, stratified according to sex, age and energy intake. Setting: Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands. Subjects: Forty-six healthy men and women completed the study. Intervention: Subjects consumed two diets supplying 69 g per day of extra virgin olive oil either rich or poor in phenols for 3 weeks each. The mean difference in phenol intake between the treatments was 18 mg per day. Vitamin E intake was low during the whole study. Fasting blood samples were taken twice at the end of each period. Results: Resistance of LDL and high density lipoprotein (HDL) to oxidation was not affected by treatment. The mean lag time of copper-induced formation of conjugated dienes was 1.6 min shorter in LDL and 0.4 min longer in HDL after the high phenol diet. Other markers of antioxidant capacity in plasma were also not affected: mean lipid hydroperoxides were 0.07 μmol/1 higher, mean malondialdehydes were 0.001 μmol/1 higher, mean protein carbonyls were 0.001 nmol/mg protein lower, and the mean ferric reducing ability of plasma (FRAP) was 0.006 mmol/1 higher after the high phenol diet. All 95␌onfidence intervals enclosed zero. Serum cholesterol concentrations were not affected by the treatment. Conclusion: Consumption of 18 mg per day of phenols from extra virgin olive oil for 3 weeks did not affect LDL or HDL oxidation or other markers of antioxidant capacity in fasting plasma samples.
    Apolipoprotein A4-1/2 polymorphism and response of serum lipids to dietary cholesterol in humans
    Weggemans, R.M. ; Zock, P.L. ; Meyboom, S. ; Funke, H. ; Katan, M.B. - \ 2000
    Journal of Lipid Research 41 (2000). - ISSN 0022-2275 - p. 1623 - 1628.
    The response of serum lipids to dietary changes is to some extent an innate characteristic. One candidate genetic factor that may affect the response of serum lipids to a change in cholesterol intake is variation in the apolipoprotein A4 gene, known as the APOA4-1/2 or apoA-IVGln360His polymorphism. However, previous studies showed inconsistent results. We therefore fed 10 men and 23 women with the APOA4-1/1 genotype and 4 men and 13 women with the APOA4-1/2 or -2/2 genotype (carriers of the APOA4-2 allele) two diets high in saturated fat, one containing cholesterol at 12.4 mg/MJ, 136.4 mg/day, and one containing cholesterol at 86.2 mg/MJ, 948.2 mg/day. Each diet was supplied for 29 days in crossover design. The mean response of serum low density lipoprotein cholesterol was 0.44 mmol/l (17 mg/dl) in both subjects with the APOA4-1/1 genotype and in subjects with the APOA4-2 allele [95␌onfidence interval of difference in response, -0.20 to 0.19 mmol/l (-8 to 7 mg/ dl)]. The mean response of high density lipoprotein cholesterol was also similar, 0.10 mmol/l (4 mg/dl), in the two APOA-4 genotype groups [95␌onfidence interval of difference in response, -0.07 to 0.08 mmol/l (-3 to 3 mg/dl)]. Thus, the APOA4-1/2 polymorphism did not affect the response of serum lipids to a change in the intake of cholesterol in this group of healthy Dutch subjects who consumed a background diet high in saturated fat. Knowledge of the APOA4-1/2 polymorphism is probably not a generally applicable tool for the identification of subjects who respond to a change in cholesterol intake.
    The apoproteina4-1/2 polymorphism does not affect the response of serum lipids to dietary cholesterol humans
    Weggemans, R.M. ; Zock, P.L. ; Meyboom, S. ; Funke, H. ; Katan, M.B. - \ 2000
    In: Abstracts XIIth International Symposium on Atherosclerosis June 25-29,2000,Stockholm,Sweden. - Sweden : Elsevier, 2000. (Atherosclerosis ; 151,suppl.1) - p. 269 - 269.
    Experimental diets with large differences in trans and saturated fatty acids for controlled feeding trials
    Meyboom, S. ; Roos, N. de; Vries, J.H.M. de - \ 2000
    In: Book of Abstracts : XIIIth International Congress of Dietetics, Edinburgh,23-27 july,2000 Edinburgh,Scotland : - p. P111 - P111.
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