Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Syntheses of alkenylated carbohydrate derivatives toward the preparation of monolayers on silicon surfaces
    Smet, L.C.P.M. de; Pukin, A.V. ; Stork, G.A. ; Vos, C.H. de; Visser, G.M. ; Zuilhof, H. ; Sudhölter, E.J.R. - \ 2004
    Carbohydrate Research : an international journal 339 (2004)15. - ISSN 0008-6215 - p. 2599 - 2605.
    protein - glycosides - acid - si
    This note describes the synthesis of different alkenylated carbohydrate derivatives suitable for direct attachment to hydrogen-terminated silicon surfaces. The derivatives were alkenylated at the C-1 position, while the remaining hydroxyl groups were protected. The development of such new carbohydrate-based sensing elements opens the access to new classes of biosensors
    Covalently Attached Saccharides on Silicon Surfaces
    Smet, L.C.P.M. de; Stork, G.A. ; Hurenkamp, G.H.F. ; Qiao-Yu, S. ; Topal, H. ; Vronen, P.J.E. ; Sieval, A.B. ; Wright, A. ; Visser, G.M. ; Zuilhof, H. ; Sudhölter, E.J.R. - \ 2003
    Journal of the American Chemical Society 125 (2003). - ISSN 0002-7863 - p. 13916 - 13917.
    hydrogen-terminated silicon - alkyl monolayers - si(111) surface - dna - hybridization - chemistry - biosensor - 1-alkenes - acid
    This paper presents the first functionalization of silicon surfaces with well-defined, covalently attached monolayers containing saccharides. Two methods were used to this aim: a thermal method (refluxing in mesitylene) and a recently developed, extremely mild photochemical method (irradiation with 447 nm at room temperature). The results were analyzed by FT-IR and angle-resolved X-ray photoelectron spectroscopy. The use of a two-dimensional detector in ARXPS allows for unparalleled, subnanometer resolution in the determination of the elemental composition of monolayers. Even for monolayers with a total thickness of only ~1.5 nm, a clear elemental depth profile can be obtained. Such analyses display for sialic acid-containing monolayers that the mild photochemical attachment does not destroy the (rather fragile) sialic acid moiety and that the sugar is present at the top of the monolayer and thus available for biological interactions.
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