Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

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Inter-laboratory comparison of nanoparticle size measurements using dynamic light scattering and differential centrifugal sedimentation
Langevin, D. ; Lozano, O. ; Salvati, A. ; Kestens, V. ; Monopoli, M. ; Raspaud, E. ; Mariot, S. ; Salonen, A. ; Thomas, S. ; Driessen, M. ; Haase, A. ; Nelissen, I. ; Smisdom, N. ; Pompa, P.P. ; Maiorano, G. ; Puntes, V. ; Puchowicz, D. ; Stępnik, M. ; Suárez, G. ; Riediker, M. ; Benetti, F. ; Mičetić, I. ; Venturini, M. ; Kreyling, W.G. ; Zande, M. van der; Bouwmeester, H. ; Milani, S. ; Rädler, J.O. ; Mülhopt, S. ; Lynch, I. ; Dawson, K. - \ 2018
NanoImpact 10 (2018). - ISSN 2452-0748 - p. 97 - 107.
Nanoparticle in vitro toxicity studies often report contradictory results with one main reason being insufficient material characterization. In particular the characterization of nanoparticles in biological media remains challenging. Our aim was to provide robust protocols for two of the most commonly applied techniques for particle sizing, i.e. dynamic light scattering (DLS) and differential centrifugal sedimentation (DCS) that should be readily applicable also for users not specialized in nanoparticle physico-chemical characterization. A large number of participants (40, although not all participated in all rounds) were recruited for a series of inter-laboratory comparison (ILC) studies covering many different instrument types, commercial and custom-built, as another possible source of variation. ILCs were organized in a consecutive manner starting with dispersions in water employing well-characterized near-spherical silica nanoparticles (nominal 19 nm and 100 nm diameter) and two types of functionalized spherical polystyrene nanoparticles (nominal 50 nm diameter). At first each laboratory used their in-house established procedures. In particular for the 19 nm silica particles, the reproducibility of the methods was unacceptably high (reported results were between 10 nm and 50 nm). When comparing the results of the first ILC round it was observed that the DCS methods performed significantly worse than the DLS methods, thus emphasizing the need for standard operating procedures (SOPs). SOPs have been developed by four expert laboratories but were tested for robustness by a larger number of independent users in a second ILC (11 for DLS and 4 for DCS). In a similar approach another SOP for complex biological fluids, i.e. cell culture medium containing serum was developed, again confirmed via an ILC with 8 participating laboratories. Our study confirms that well-established and fit-for-purpose SOPs are indispensable for obtaining reliable and comparable particle size data. Our results also show that these SOPs must be optimized with respect to the intended measurement system (e.g. particle size technique, type of dispersant) and that they must be sufficiently detailed (e.g. avoiding ambiguity regarding measurand definition, etc.). SOPs may be developed by a small number of expert laboratories but for their widespread applicability they need to be verified by a larger number of laboratories.
Chapter three Bridging the gaps between design and use: Developing tools to support environmental management and policy
McIntosh, B.S. ; Giupponi, C. ; Voinov, A.A. ; Smith, C. ; Matthews, K.B. ; Monticino, M. ; Kolkman, M.J. ; Crossman, N. ; Ittersum, M.K. van; Haase, D. ; Haase, A. ; Mysiak, J. ; Groot, J.C.J. ; Sieber, S. ; Verweij, P. ; Quinn, N. ; Waeger, P. ; Gaber, N. ; Hepting, D. ; Scholten, H. ; Sulis, A. ; Delden, H. van; Gaddis, E. ; Assaf, H. - \ 2008
In: Developments in integrated environmental assessment / Jakeman, A.J., Voinov, A.A., Rizzoli, A.E., Chen, S.H., Elsevier (Environmental Modelling, Software and Decision Support Volume 3) - ISBN 9780080568867 - p. 33 - 48.
Integrated assessment models, decision support systems (DSS) and Geographic Information Systems (GIS) are examples of a growing number of computer-based tools designed to provide decision and information support to people engaged in formulating and implementing environmental policy and management. It is recognised that environmental policy and management users are often not as receptive to using such tools as desired but that little research has been done to uncover and understand the reasons. There is a diverse range of environmental decision and information support tools (DISTs) with uses including organisational and participatory decision support, and scientific research. The different uses and users of DISTs each present particular needs and challenges to the tool developers. The lack of appreciation of the needs of end-users by developers has contributed to the lack of success of many DISTs. Therefore it is important to engage users and other stakeholders in the tool development process to help bridge the gap between design and use. Good practice recommendations for developers to involve users include being clear about the purpose of the tool, working collaboratively with other developers and stakeholders, and building social and scientific credibility
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