Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions
Duchemin, S.I. ; Bovenhuis, H. ; Stoop, W.M. ; Bouwman, A.C. ; Arendonk, J.A.M. van; Visker, M.H.P.W. - \ 2013
Journal of Dairy Science 96 (2013)1. - ISSN 0022-0302 - p. 592 - 604.
conjugated linoleic-acid - coa-diacylglycerol acyltransferase - dairy-cows - short communication - production traits - desaturase - parameters - enzyme - cla - biohydrogenation
Milk fat composition shows substantial seasonal variation, most of which is probably caused by differences in the feeding of dairy cows. The present study aimed to know whether milk fat composition in winter is genetically the same trait as milk fat composition in summer. For this purpose, we estimated heritabilities, genetic correlations, effects of acyl-coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) K232A, and stearoyl-coenzyme A desaturase 1 (SCD1) A293V polymorphisms for milk fat composition in winter and summer, and tested for genotype by season interactions of DGAT1 K232A and SCD1 A293V polymorphisms. Milk samples were obtained from 2,001 first-lactation Dutch Holstein-Friesian cows, most with records in both winter and summer. Summer milk contained higher amounts of unsaturated fatty acids (FA) and lower amounts of saturated FA compared with winter milk. Heritability estimates were comparable between seasons: moderate to high for short- and medium-chain FA (0.33 to 0.74) and moderate for long-chain FA (0.19 to 0.43) in both seasons. Genetic correlations between winter and summer milk were high, indicating that milk fat composition in winter and in summer can largely be considered as genetically the same trait. Effects of DGAT1 K232A and SCD1 A293V polymorphisms were similar across seasons for most FA. Allele DGAT1 232A in winter as well as in summer milk samples was negatively associated with most FA with less than 18 carbons, saturated FA, saturated FA to unsaturated FA ratio, and C10 to C16 unsaturation indices, and was positively associated with C14:0, unsaturated C18, unsaturated FA, and C18 and conjugated linoleic acid unsaturation indices. Allele SCD1 293V in winter as well as in summer milk samples was negatively associated with C18:0, C10:1 to cis-9 C14:1, trans-11 C18:1, and C10 to C14 unsaturation indices, and positively associated with C8:0 to C14:0, cis-9 C16:1, and C16 to conjugated linoleic acid unsaturation indices. In addition, significant DGAT1 K232A by season interaction was found for some FA and SCD1 A293V by season interaction was only found for trans-11 C18:1. These interactions were due to scaling of genotype effects.
Milk genomics
Mullaart, E. ; Heck, J.M.L. ; Stoop, W.M. ; Schennink, A. ; Schopen, G.C.B. ; Visker, M.H.P.W. ; Arendonk, J.A.M. van - \ 2009
Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids
Schennink, A. ; Stoop, W.M. ; Visker, M.H.P.W. ; Poel, J.J. van der; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2009
Journal of Dairy Science 92 (2009)9. - ISSN 0022-0302 - p. 4676 - 4682.
dairy-cattle - genetic-parameters - f-2 population - rat-liver - fish-oil - dgat1 - polymorphism - trans - cows - qtl
We present the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in long-chain milk fatty acids. Milk-fat composition phenotypes were available on 1,905 Dutch Holstein-Friesian cows. A total of 849 cows and their 7 sires were genotyped for 1,341 single nucleotide polymorphisms across all Bos taurus autosomes (BTA). We detected significant QTL on BTA14, BTA15, and BTA16: for C18:1 cis-9, C18:1 cis-12, C18:2 cis-9,12, CLA cis-9,trans-11, C18:3 cis-9,12,15, the C18 index, the total index, total saturated fatty acids, total unsaturated fatty acids (UFA), and the ratio of saturated fatty acids:unsaturated fatty acids on BTA14; for C18:1 trans fatty acids on BTA15; and for the C18 and CLA indices on BTA16. The QTL explained 3 to 19% of the phenotypic variance. Suggestive QTL were found on 16 other chromosomes. The diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism on BTA14, which is known to influence fatty acid composition, most likely explains the QTL that was detected on BTA14
Melkvet met meerwaarde
Stoop, W.M. ; Arendonk, J.A.M. van; Bovenhuis, H. ; Heck, J. - \ 2009
Veeteelt 26 (2009)6. - ISSN 0168-7565 - p. 12 - 14.
melkveehouderij - melkvee - dierveredeling - melkvet - samenstelling - dairy farming - dairy cattle - animal breeding - milk fat - composition
Fokken op melkvet richt zich vooralsnog alleen op de hoeveelheid vet. Onderzoekers van Wageningen Universiteit tonen aan dat niet alleen de hoeveelheid melkvet, maar ook de melkvetsamenstelling met behulp van fokkerij verbeterd kan worden
Melk nog verder verbeteren door fokkerijmaatregelen : eerste drie promoties op basis van Milk Genomics Initiative (interview met Johan van Arendonk)
Blom, J. ; Arendonk, J.A.M. van; Stoop, W.M. ; Schennink, A. ; Heck, J. - \ 2009
VoedingsMagazine 22 (2009)3. - ISSN 0922-8012 - p. 4 - 10.
melksamenstelling - dierveredeling - genetische variatie - melkvetpercentage - onverzadigde vetzuren - melkeiwit - genexpressieanalyse - milk composition - animal breeding - genetic variation - milk fat percentage - unsaturated fatty acids - milk protein - genomics
In 2004, the Milk Genomics Initiative (NGI) was launched – an exploration of the possibility to change the composition of milk though breeding measures. Five years later, it has become a fact that it is possible indeed, through selection of the most suitable animals, to attune the composition of both dairy fat and dairy protein to specific wishes. In milk fat the content of saturated fatty acids can be raised while in milk protein the casein concentration can be increased. In March and April 2009, the first three MGI research assistants obtained their doctoral degree on the basis of MGI research. An interview with the MGI project manager, Prof. Johan van Arendonk
Genome-wide scan for bovine milk-fat composition. I. Quantitative trait loci for short- and medium-chain fatty acids
Stoop, W.M. ; Schennink, A. ; Visker, M.H.P.W. ; Mullaart, E. ; Arendonk, J.A.M. van; Bovenhuis, H. - \ 2009
Journal of Dairy Science 92 (2009)9. - ISSN 0022-0302 - p. 4664 - 4675.
stearoyl-coa desaturase - half-sib populations - growth-hormone - dairy-cattle - alternative transcript - genetic-parameters - carboxylase-alpha - mammary-gland - ppar-gamma - fasn gene
A genome-wide scan was performed to identify quantitative trait loci (QTL) for short- and medium-chain fatty acids (expressed in wt/wt %). Milk samples were available from 1,905 cows from 398 commercial herds in the Netherlands, and milk-fat composition was measured by gas chromatography. DNA was available from 7 of the paternal half-sib families: 849 cows and their 7 sires. A genetic map was constructed comprising 1,341 SNP and 2,829 cM, with an average information content of 0.83. Multimarker interval mapping was used in an across-family regression on corrected phenotypes for the 7 half-sib families. Four QTL were found: on Bos taurus autosome (BTA) 6, a QTL was identified for C6:0 and C8:0; on BTA14, a QTL was identified for fat percentage, all odd-chain fatty acids, and C14:0, C16:0, C16:1, and their unsaturation indices; on BTA19, a QTL affected C14:0; and on BTA26, a QTL was identified for the monounsaturated fatty acids and their unsaturation indices. The QTL explained 3 to 19% of phenotypic variance. Furthermore, 49 traits with suggestive evidence for linkage were found on 21 chromosomes. Additional analyses revealed that the QTL on BTA14 was most likely caused by a mutation in DGAT1, whereas the QTL on BTA26 was most likely caused by a mutation in the SCD1 gene. Quantitative trait loci that affect specific fatty acids might increase the understanding of physiological processes regarding fat synthesis and the position of the causal genes
Effect of lactation stage and energy status on milk fat composition of Holstein-Friesian cows
Stoop, W.M. ; Bovenhuis, H. ; Heck, J.M.L. ; Arendonk, J.A.M. van - \ 2009
Journal of Dairy Science 92 (2009)4. - ISSN 0022-0302 - p. 1469 - 1478.
dairy-cows - genetic-parameters - acid-composition - balance - prediction - cattle - fertility - yield - model
The effects of lactation stage, negative energy balance (NEB), and milk fat depression (MFD) were estimated on detailed milk fat composition in primiparous Holstein-Friesian cows. One morning milk sample was collected from each of 1,933 cows from 398 commercial Dutch herds in winter 2005. Milk fat composition was measured using gas chromatography, and fat and protein percentage were measured using infrared spectrometry. Each fatty acid changed 0.5 to 1 phenotypic standard deviation over lactation, except odd-chain C5:0 to C15:0, branched-chain fatty acids, and trans-10, cis-12 conjugated linoleic acid (CLA). The greatest change was an increase from 31.2 to 33.3% (wt/wt) for C16:0 from d 80 to 150 of lactation. Energy status was estimated for each cow as the deviation from each average lactation fat-to-protein ratio (FPdev). A high FPdev (>0.12) indicated NEB. Negative energy balance was associated with an increase in C16:0 (0.696 ± 0.178) and C18:0 (0.467 ± 0.093), which suggested mobilization of body fat reserves. Furthermore, NEB was associated with a decrease in odd-chain C5:0 to C15:0 (¿0.084 ± 0.020), which might reflect a reduced allocation of C3 components to milk fat synthesis. A low FPdev indicated MFD (
Genetic variation in bovine milk fat composition
Stoop, W.M. - \ 2009
Wageningen University. Promotor(en): Johan van Arendonk, co-promotor(en): Henk Bovenhuis. - [S.l.] : S.n. - ISBN 9789085853558
melk - melkvet - melksamenstelling - genetische variatie - selectie - dierveredeling - selectief fokken - vetzuren - milk - milk fat - milk composition - genetic variation - selection - animal breeding - selective breeding - fatty acids
In her thesis, Stoop shows that there is considerable genetic variation in milk fat composition, which opens opportunities to improve milk fat composition by selective breeding. Short and medium chain fatty acids had high heritabilities, whereas variation due to herd (mainly feed effects) was moderate. Long chain fatty acids had moderate heritabilities, whereas variation due to herd was high. Several genomic regions (QTL) with effect on short and medium chain, long chain, or both types of fatty acids were identified. Differences in results could be explained by the origin of the fatty acids; short and medium chain fatty acids are predominantly synthesized by the cow in the mammary gland, whereas long chain fatty acid are mainly of dietary origin. Results show that milk fat composition can be improved by selective breeding, which offers opportunities to meet consumers’ demands regarding health and technological aspects.
Quantitative trait loci for milk-fat composition in Dutch Holstein Friesians
Schennink, A. ; Stoop, W.M. ; Bovenhuis, H. ; Heck, J.M.L. ; Koks, P.D. ; Visker, M.H.P.W. ; Arendonk, J.A.M. van - \ 2008
Quantitative trait loci for milk-fat composition in Dutch Holstein Friesians
Schennink, A. ; Stoop, W.M. ; Visker, M.H.P.W. ; Koks, P.D. ; Mullaart, E. ; Arendonk, J.A.M. van; Bovenhuis, H. - \ 2008
In: Book of abstracts of the XXXI Conference of the International Society for Animal Genetics, 20 - 24 July, Amsterdam. the Netherlands - p. 2097 - 2097.
QTL for milk fat composition: short, medium, and long chain fatty acids
Stoop, W.M. ; Schennink, A. ; Visker, M.H.P.W. ; Mullaart, E. ; Poel, J.J. van der; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2008
Genome-wide scan for short and medium chain milk fatty acids
Stoop, W.M. ; Schennink, A. ; Visker, M.H.P.W. ; Mullaart, E. ; Arendonk, J.A.M. van; Bovenhuis, H. - \ 2008
melkvee - zwartbont - melkvet - vetzuren met een lange keten - loci voor kwantitatief kenmerk - merkers - genotyping - genexpressieanalyse - dairy cattle - holstein-friesian - milk fat - long chain fatty acids - quantitative trait loci - markers - genotyping - genomics
Aim of this research was to identify Quantitative Trait Loci (QTL) for long chain milk fatty acids. Therefore 1905 Dutch Holstein Friesian heifers were phenotyped. One of the conclusions was that the identification of QTL for long chain fatty acids, and in particular for C18:1trans fatty acids, strongly supports the hypothesis of a genetic component for these fatty acids
Genetic Parameters for Major Milk Fatty Acids and Milk Production Traits of Dutch Holstein-Friesians
Stoop, W.M. ; Arendonk, J.A.M. van; Heck, J.M.L. ; Valenberg, H.J.F. van; Bovenhuis, H. - \ 2008
Journal of Dairy Science 91 (2008)1. - ISSN 0022-0302 - p. 385 - 394.
bovine-milk - cow milk - associations - lipids
The objective of this study was to estimate genetic parameters for major milk fatty acids and milk production traits. One morning milk sample was collected from 1,918 Holstein-Friesian heifers located in 398 commercial herds in the Netherlands. Each sample was analyzed for total percentages of fat and protein, and for detailed fatty acid percentages (computed as fatty acid weight as a proportion of total fat weight). Intraherd heritabilities were high for C4:0 to C16:0, ranging from 0.42 for C4:0 to 0.71 for C10:0. Saturated and unsaturated C18 fatty acids had intraherd heritability estimates of approximately 0.25, except for C18:2 cis-9, trans-11, which was 0.42. Standard errors of the heritabilities were between 0.07 and 0.12. Genetic correlations were high and positive among C4:0 to C14:0, as well as among unsaturated C18, but correlations of C4:0 to C14:0 with unsaturated C18 were generally weak. The genetic correlation of C16:0 with fat percentage was positive (0.65), implying that selection for fat percentage should result in a correlated increase of C16:0, whereas unsaturated C18 fatty acids decreased with increasing fat percentage (¿0.74). Milk fat composition can be changed by means of selective breeding, which offers opportunities to meet consumer demands regarding health and technological aspects.
Dutch milk genomics initiative reveals large genetic variation in milk-fat composition
Schennink, A. ; Stoop, W.M. ; Visker, M.H.P.W. ; Heck, J.M.L. ; Bovenhuis, H. ; Valenberg, H.J.F. van; Hooijdonk, A.C.M. van; Arendonk, J.A.M. van - \ 2007
Milk-fat composition of dairy cows can be improved by use of genetic variation
Schennink, A. ; Stoop, W.M. ; Visker, M.H.P.W. ; Heck, J.M.L. ; Bovenhuis, H. ; Poel, J.J. van der; Arendonk, J.A.M. van; Valenberg, H.J.F. van - \ 2007
DGAT1 underlies large genetic variation in milk-fat composition of dairy cows
Schennink, A. ; Stoop, W.M. ; Visker, M.H.P.W. ; Heck, J.M.L. ; Bovenhuis, H. ; Poel, J.J. van der; Valenberg, H.J.F. van; Arendonk, J.A.M. van - \ 2007
Animal Genetics 38 (2007)5. - ISSN 0268-9146 - p. 467 - 473.
dierveredeling - melkkoeien - melkvee - zwartbont - melksamenstelling - melkvet - vetzuren - lactatie - genetische variatie - genotypen - genetische parameters - heritability - selectief fokken - nederland - animal breeding - dairy cows - dairy cattle - holstein-friesian - milk composition - milk fat - fatty acids - lactation - genetic variation - genotypes - genetic parameters - selective breeding - netherlands - coa-diacylglycerol acyltransferase - serum-cholesterol - production traits - dietary-fat - bovine - acids - cattle - yield - parameters - disease
Dietary fat may play a role in the aetiology of many chronic diseases. Milk and milk-derived foods contribute substantially to dietary fat, but have a fat composition that is not optimal for human health. We measured the fat composition of milk samples in 1918 Dutch Holstein Friesian cows in their first lactation and estimated genetic parameters for fatty acids. Substantial genetic variation in milk-fat composition was found: heritabilities were high for short- and medium-chain fatty acids (C4:0¿C16:0) and moderate for long-chain fatty acids (saturated and unsaturated C18). We genotyped 1762 cows for the DGAT1 K232A polymorphism, which is known to affect milk-fat percentage, to study the effect of the polymorphism on milk-fat composition. We found that the DGAT1 K232A polymorphism has a clear influence on milk-fat composition. The DGAT1 allele that encodes lysine (K) at position 232 (232K) is associated with more saturated fat; a larger fraction of C16:0; and smaller fractions of C14:0, unsaturated C18 and conjugated linoleic acid (P <0.001). We conclude that selective breeding can make a significant contribution to change the fat composition of cow¿s milk.
Genetic parameters for milk urea nitrogen in relation to milk production traits
Stoop, W.M. ; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2007
Journal of Dairy Science 90 (2007). - ISSN 0022-0302 - p. 1981 - 1986.
dairy-cows - nonprotein nitrogen - reproductive-performance - statistical evaluation - holstein cows - protein - herds - heritability - lactation - cattle
The aim of this study was to estimate genetic parameters for test-day milk urea nitrogen (MUN) and its relationships with milk production traits. Three test-day morning milk samples were collected from 1,953 Holstein-Friesian heifers located on 398 commercial herds in the Netherlands. Each sample was analyzed for somatic cell count, net energy concentration, MUN, and the percentage of fat, protein, and lactose. Genetic parameters were estimated using an animal model with covariates for days in milk and age at first calving, fixed effects for season of calving and effect of test or proven bull, and random effects for herd-test day, animal, permanent environment, and error. Coefficient of variation for MUN was 33%. Estimated heritability for MUN was 0.14. Phenotypic correlation of MUN with each of the milk production traits was low. The genetic correlation was close to zero for MUN and lactose percentage (¿0.09); was moderately positive for MUN and net energy concentration of milk (0.19), fat yield (0.41), protein yield (0.38), lactose yield (0.22), and milk yield (0.24), and percentage of fat (0.18), and percentage of protein (0.27); and was high for MUN and somatic cell score (0.85). Herd-test day explained 58% of the variation in MUN, which suggests that management adjustments at herd-level can reduce MUN. This study shows that it is possible to influence MUN by herd practice and by genetic selection
Genetic and Herd effects on Milk Composition in Dutch Holstein-Friesian Primiparous Cows
Stoop, W.M. ; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2006
Genetic parameters of milk urea in relation to milk production traits
Stoop, W.M. ; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2006
Genetic parameters of milk urea in relation to milk production traits
Stoop, W.M. ; Bovenhuis, H. ; Arendonk, J.A.M. van - \ 2006
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