Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Records 1 - 11 / 11

  • help
  • print

    Print search results

  • export

    Export search results

  • alert
    We will mail you new results for this query: metisnummer==1044497
Check title to add to marked list
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
Haas, B.J. ; Kamoun, S. ; Zody, M.C. ; Jiang, R.H.Y. ; Handsaker, R.E. ; Cano, L.M. ; Grabherr, M. ; Kodira, C.D. ; Raffaele, S. ; Torto-Alalibo, T. ; Bozkurt, T.O. ; Ah-Fong, A.M.V. ; Alvarado, L. ; Anderson, V.L. ; Armstrong, M.R. ; Avrova, A. ; Baxter, L. ; Beynon, J. ; Boevink, P.C. ; Bollmann, S.R. ; Bos, J.I.B. ; Bulone, V. ; Cai, G. ; Cakir, C. ; Carrington, J.C. ; Chawner, M. ; Conti, L. ; Costanzo, S. ; Ewan, R. ; Fahlgren, N. ; Fischbach, M.A. ; Fugelstad, J. ; Gilroy, E.M. ; Gnerre, S. ; Green, P.J. ; Grenville-Briggs, L.J. ; Griffith, J. ; Grunwald, N.J. ; Horn, K. ; Horner, N.R. ; Hu, C.H. ; Huitema, E. ; Jeong, D.H. ; Jones, A.M.E. ; Jones, J.D.G. ; Jones, R.W. ; Karlsson, E.K. ; Kunjeti, S.G. ; Lamour, K. ; Liu, Z. ; Ma, L. ; Maclean, D. ; Chibucos, M.C. ; McDonald, H. ; McWalters, J. ; Meijer, H.J.G. ; Morgan, W. ; Morris, P.F. ; Munro, C.A. ; O'Neill, K. ; Ospina-Giraldo, M. ; Pinzon, A. ; Pritchard, L. ; Ramsahoye, B. ; Ren, Q. ; Restrepo, S. ; Roy, S. ; Sadanandom, A. ; Savidor, A. ; Schornack, S. ; Schwartz, D.C. ; Schumann, U.D. ; Schwessinger, B. ; Seyer, L. ; Sharpe, T. ; Silvar, C. ; Song, J. ; Studholme, D.J. ; Sykes, S. ; Thines, M. ; Vondervoort, P.J.I. van de; Phuntumart, V. ; Wawra, S. ; Weide, R. ; Win, J. ; Young, C. ; Zhou, S. ; Fry, W. ; Meyers, B.C. ; West, P. van; Ristaino, J. ; Govers, F. ; Birch, P.R.J. ; Whisson, S.C. ; Judelson, H.S. ; Nusbaum, C. - \ 2009
Nature 461 (2009). - ISSN 0028-0836 - p. 393 - 398.
effector proteins - rxlr effectors - cell-death - plant - avirulence - avr3a - resistance - infection - genes
Phytophthora infestans is the most destructive pathogen of potato and a model organism for the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms such as brown algae and diatoms. As the agent of the Irish potato famine in the mid-nineteenth century, P. infestans has had a tremendous effect on human history, resulting in famine and population displacement(1). To this day, it affects world agriculture by causing the most destructive disease of potato, the fourth largest food crop and a critical alternative to the major cereal crops for feeding the world's population(1). Current annual worldwide potato crop losses due to late blight are conservatively estimated at $6.7 billion(2). Management of this devastating pathogen is challenged by its remarkable speed of adaptation to control strategies such as genetically resistant cultivars(3,4). Here we report the sequence of the P. infestans genome, which at similar to 240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates. Its expansion results from a proliferation of repetitive DNA accounting for similar to 74% of the genome. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of specific families of secreted disease effector proteins, including many genes that are induced during infection or are predicted to have activities that alter host physiology. These fast-evolving effector genes are localized to highly dynamic and expanded regions of the P. infestans genome. This probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Host-pathogen interaction drives genome plasticity in the late blight pathogen
Jiang, R.H.Y. ; Haas, B. ; Zody, M.C. ; Raffaele, S. ; Bozkurt, T. ; Cano, L. ; Versluis, H.P. ; Govers, F. ; Kamoun, S. ; Nusbaum, C. - \ 2009
- p. 1 - 1.
Phytophthora infestans causes late blight of potato and was the proximal cause of the Great Irish Famine. It remains a devastatingagricultural problem as it rapidly circumvents efforts at control by use of resistant cultivars and fungicides. The ~240 Mb genome of P. infestans is the largest and most complex in the chromalveolate lineage, and its sequence reveals features that illuminate its success as a pathogen. Comparison to other Phytophthora genomes shows massive expansion and a high rate of turnover in the content of genes encoding secreted proteins, including the host-translocated effectors of the RXLR class. P. infestans also has a vastly expanded array of Crinkler family genes. New functional analyses show that several classes of Crinklers trigger cell death when expressed inside plant cells, suggesting that they form a new class of host-translocated effectors. The genome structure itself likely plays a role in successful adaptation. The genome includes large repeat-rich regions where genes and gene order are not conserved. These regions are significantly enriched in rapidly evolving genes encoding secreted proteins such as RXLRs and Crinklers, and may provide a mechanism for easily duplicating successful effectors and deleting those that trigger resistance. For example, the Avr1 avirulence gene occurs at duplicated loci, and its avirulence allele is entirely absent in virulent strains. Sample sequencing of several strains of P. infestans and closely related Phytophthora species shows extensive copy number variation in the majority of secreted effectors, suggesting this as a common mechanism for evading resistance.
Genome plasticity revealed by comparative genomics of Phytophthora isolates, sibling species and distant relatives
Jiang, R.H.Y. ; Versluis, H.P. ; Govers, F. ; Haas, B. ; Handsaker, B. ; Nusbaum, C. ; Zody, M.C. - \ 2008
In: Book of Abstracts Annual Meeting Oomycete Molecular Genetics Network, Birnam, Scotland, United Kingdom, 6-9 May 2008. - - p. 14 - 14.
Genome dynamics in the pathogen/host arms race: Initial analysis of the Phytophthora infestans genome
Zody, M.C. ; Jiang, R.H.Y. ; Handsaker, R. ; Grabherr, M. ; Kodira, C.D. ; Govers, F. ; Birch, P. ; Whisson, S. ; Win, J. ; Judelson, H. ; Ristaino, J.B. ; Fry, W.E. ; Kamoun, S. ; Nusbaum, C. - \ 2007
In: Book of Abstracts American Phytopathological Society Annual Meeting, San Diego, California, USA, 28 July - 1 August 2007. - - p. S146 - S146.
The effector secretome of Phytophthora infestans: structure and function
Kamoun, S. ; Win, J. ; Morgan, W. ; Oh, S.K. ; Young, C. ; Jiang, R. ; Govers, F. ; Zody, M.C. ; Nusbaum, C. - \ 2007
In: Book of Abstracts XXIV Fungal Genetics Conference, Pacific Grove, California, USA, 20-25 March 2007 - p. 85 - 85.
The effector secretome of Phytophthora infestans: structure and function
Kamoun, S. ; Win, J. ; Morgan, W. ; Oh, S.K. ; Young, C. ; Jiang, R. ; Govers, F. ; Zody, M.C. ; Nusbaum, C. - \ 2007
In: Book of Abstracts Oomycete Molecular Genetics Network Workshop, Pacific Grove, California, USA 18-20 March 2007 - p. 20 - 20.
Identification and characterization of repeats in genomes of Phytophthora species
Zody, M.C. ; Grabherr, M. ; Jiang, R.H.Y. ; Nusbaum, C. - \ 2007
In: Book of Abstracts Oomycete Molecular Genetics Network Workshop, Pacific Grove, California, USA 18-20 March 2007 - p. 13 - 13.
Genomic discovery and evolutionary patterns of the effector proteins in Phytophthora
Jiang, R.H.Y. ; Govers, F. ; Zody, M.C. ; Nusbaum, C. ; Tripathy, S. ; Tyler, B.M. - \ 2007
In: Book of Abstracts XXIV Fungal Genetics Conference, Pacific Grove, California, USA, 20-25 March 2007 - p. 154 - 154.
Plasticity of the Phytophthora genome - amplifications and retrotransposons
Jiang, R.H.Y. ; Weide, R. ; Zody, M.C. ; Nusbaum, C. ; Govers, F. - \ 2007
In: Book of Abstracts Oomycete Molecular Genetics Network Workshop, Pacific Grove, California, USA 18-20 March 2007 - p. 13 - 13.
Sequencing the Phytophthora infestans genome: preliminary studies
Zody, M.C. ; O'Neill, K. ; Handsaker, B. ; Karlsson, E. ; Govers, F. ; Vondervoort, P. van de; Weide, R. ; Whisson, S. ; Birch, P. ; Ma LiJun, ; Birren, B. ; Ristaino, J. ; Fry, W. ; Judelson, H. ; Kamoun, S. ; Nusbaum, C. - \ 2005
Sequencing the Phytophthora infestans Genome: Preliminary Studies
O'Neill, K. ; Zody, M.C. ; Karlsson, E. ; Govers, F. ; Vondervoort, P.J.I. van de; Weide, R.L. ; Whisson, S. ; Birch, P. ; Ma, L. ; Birren, B. ; Fry, W. ; Judelson, H. ; Kamoun, S. ; Nusbaum, C. - \ 2004
In: Book of Abstracts annual meeting NSF Phytophthora Molecular Genetics Network, New Orleans LA, USA, 21-23 May 2004 - p. 5 - 5.
Check title to add to marked list

Show 20 50 100 records per page

 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.